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Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.
Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. Jiang J, et al. Among authors: cleveland dw. Neuron. 2016 May 4;90(3):535-50. doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21. Neuron. 2016. PMID: 27112497 Free PMC article.
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant.
Williamson TL, Bruijn LI, Zhu Q, Anderson KL, Anderson SD, Julien JP, Cleveland DW. Williamson TL, et al. Among authors: cleveland dw. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9631-6. doi: 10.1073/pnas.95.16.9631. Proc Natl Acad Sci U S A. 1998. PMID: 9689132 Free PMC article.
Gene therapy for ALS delivers.
Boillée S, Cleveland DW. Boillée S, et al. Among authors: cleveland dw. Trends Neurosci. 2004 May;27(5):235-8. doi: 10.1016/j.tins.2004.03.002. Trends Neurosci. 2004. PMID: 15111001 Review.
Antisense oligonucleotide therapy for neurodegenerative disease.
Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW. Smith RA, et al. Among authors: cleveland dw. J Clin Invest. 2006 Aug;116(8):2290-6. doi: 10.1172/JCI25424. Epub 2006 Jul 27. J Clin Invest. 2006. PMID: 16878173 Free PMC article.
423 results