Thakkar S - Search Results

1

The FDA's Experience with Emerging Genomics Technologies-Past, Present, and Future.

Xu J, Thakkar S, Gong B, Tong W. Xu J, et al. Among authors: thakkar s. AAPS J. 2016 Jul;18(4):814-8. doi: 10.1208/s12248-016-9917-y. Epub 2016 Apr 26. AAPS J. 2016. PMID: 27116022 Free PMC article. Review.

2

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W. Chen M, et al. Among authors: thakkar s. Drug Discov Today. 2016 Apr;21(4):648-53. doi: 10.1016/j.drudis.2016.02.015. Epub 2016 Mar 3. Drug Discov Today. 2016. PMID: 26948801 Review. No abstract available.

3

Comprehensive Assessments of RNA-seq by the SEQC Consortium: FDA-Led Efforts Advance Precision Medicine.

Xu J, Gong B, Wu L, Thakkar S, Hong H, Tong W. Xu J, et al. Among authors: thakkar s. Pharmaceutics. 2016 Mar 15;8(1):8. doi: 10.3390/pharmaceutics8010008. Pharmaceutics. 2016. PMID: 26999190 Free PMC article. Review.

4

The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury.

Thakkar S, Chen M, Fang H, Liu Z, Roberts R, Tong W. Thakkar S, et al. Expert Rev Gastroenterol Hepatol. 2018 Jan;12(1):31-38. doi: 10.1080/17474124.2018.1383154. Epub 2017 Oct 9. Expert Rev Gastroenterol Hepatol. 2018. PMID: 28931315

5

Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.

Hong H, Thakkar S, Chen M, Tong W. Hong H, et al. Among authors: thakkar s. Sci Rep. 2017 Dec 11;7(1):17311. doi: 10.1038/s41598-017-17701-7. Sci Rep. 2017. PMID: 29229971 Free PMC article.

6

Scaling bioinformatics applications on HPC.

Mikailov M, Luo FJ, Barkley S, Valleru L, Whitney S, Liu Z, Thakkar S, Tong W, Petrick N. Mikailov M, et al. Among authors: thakkar s. BMC Bioinformatics. 2017 Dec 28;18(Suppl 14):501. doi: 10.1186/s12859-017-1902-7. BMC Bioinformatics. 2017. PMID: 29297287 Free PMC article.

7

Emerging technologies for food and drug safety.

Slikker W Jr, de Souza Lima TA, Archella D, de Silva JB Junior, Barton-Maclaren T, Bo L, Buvinich D, Chaudhry Q, Chuan P, Deluyker H, Domselaar G, Freitas M, Hardy B, Eichler HG, Hugas M, Lee K, Liao CD, Loo LH, Okuda H, Orisakwe OE, Patri A, Sactitono C, Shi L, Silva P, Sistare F, Thakkar S, Tong W, Valdez ML, Whelan M, Zhao-Wong A. Slikker W Jr, et al. Among authors: thakkar s. Regul Toxicol Pharmacol. 2018 Oct;98:115-128. doi: 10.1016/j.yrtph.2018.07.013. Epub 2018 Jul 23. Regul Toxicol Pharmacol. 2018. PMID: 30048704 Free article.

8

Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA.

Wu L, Ingle T, Liu Z, Zhao-Wong A, Harris S, Thakkar S, Zhou G, Yang J, Xu J, Mehta D, Ge W, Tong W, Fang H. Wu L, et al. Among authors: thakkar s. BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):97. doi: 10.1186/s12859-019-2628-5. BMC Bioinformatics. 2019. PMID: 30871458 Free PMC article.

9

Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity.

Thakkar S, Li T, Liu Z, Wu L, Roberts R, Tong W. Thakkar S, et al. Drug Discov Today. 2020 Jan;25(1):201-208. doi: 10.1016/j.drudis.2019.09.022. Epub 2019 Nov 1. Drug Discov Today. 2020. PMID: 31669330 Free article. Review.

10

Can Transcriptomic Profiles from Cancer Cell Lines Be Used for Toxicity Assessment?

Liu Z, Zhu L, Thakkar S, Roberts R, Tong W. Liu Z, et al. Among authors: thakkar s. Chem Res Toxicol. 2020 Jan 21;33(1):271-280. doi: 10.1021/acs.chemrestox.9b00288. Epub 2019 Dec 20. Chem Res Toxicol. 2020. PMID: 31808688 Free article.

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