Ma S - Search Results

1

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.

Le H, Fan PW, Wong S, Ma S, Driscoll JP, Hop CE, Cyrus Khojasteh S. Le H, et al. Among authors: ma s. Drug Metab Lett. 2016;10(2):136-43. doi: 10.2174/1872312810666160427104954. Drug Metab Lett. 2016. PMID: 27117606

2

Investigations into the mechanisms of pyridine ring cleavage in vismodegib.

Khojasteh SC, Yue Q, Ma S, Castanedo G, Chen JZ, Lyssikatos J, Mulder T, Takahashi R, Ly J, Messick K, Jia W, Liu L, Hop CE, Wong H. Khojasteh SC, et al. Among authors: ma s. Drug Metab Dispos. 2014 Mar;42(3):343-51. doi: 10.1124/dmd.113.055715. Epub 2014 Jan 3. Drug Metab Dispos. 2014. PMID: 24389420

3

Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.

Takahashi R, Ma S, Deese A, Yue Q, Kim-Kang H, Yi Y, Siu M, Hunt KW, Kallan NC, Hop CE, Liu X, Khojasteh SC. Takahashi R, et al. Among authors: ma s. Drug Metab Dispos. 2014 May;42(5):890-8. doi: 10.1124/dmd.114.057141. Epub 2014 Mar 4. Drug Metab Dispos. 2014. PMID: 24595682

4

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp.

Takahashi R, Ma S, Yue Q, Kim-Kang H, Yi Y, Lyssikatos JP, Regal K, Hunt KW, Kallan NC, Siu M, Hop CE, Liu X, Khojasteh SC. Takahashi R, et al. Among authors: ma s. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):171-85. doi: 10.1007/s13318-014-0198-5. Epub 2014 Apr 3. Eur J Drug Metab Pharmacokinet. 2015. PMID: 24696325

5

Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.

Liang X, Yang L, Qin AR, Ly J, Liederer BM, Messick K, Ma S, Zak M, Dragovich PS, Dean BJ, Hop CE, Deng Y. Liang X, et al. Among authors: ma s. Bioanalysis. 2014 Jun;6(11):1445-57. doi: 10.4155/bio.14.8. Bioanalysis. 2014. PMID: 25046046

6

Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.

Takahashi RH, Ma S, Robinson SJ, Yue Q, Choo EF, Khojasteh SC. Takahashi RH, et al. Among authors: ma s. Drug Metab Dispos. 2015 Dec;43(12):1929-33. doi: 10.1124/dmd.115.067181. Epub 2015 Oct 5. Drug Metab Dispos. 2015. PMID: 26438627

7

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Takahashi RH, Choo EF, Ma S, Wong S, Halladay J, Deng Y, Rooney I, Gates M, Hop CE, Khojasteh SC, Dresser MJ, Musib L. Takahashi RH, et al. Among authors: ma s. Drug Metab Dispos. 2016 Jan;44(1):28-39. doi: 10.1124/dmd.115.066282. Epub 2015 Oct 8. Drug Metab Dispos. 2016. PMID: 26451002 Clinical Trial.

8

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.

Takahashi RH, Ma S, Yue Q, Kim-Kang H, Yi Y, Ly J, Boggs JW, Fettes A, McClory A, Deng Y, Hop CE, Khojasteh SC, Choo EF. Takahashi RH, et al. Among authors: ma s. Xenobiotica. 2017 Jan;47(1):50-65. doi: 10.3109/00498254.2016.1157645. Epub 2016 Apr 8. Xenobiotica. 2017. PMID: 27055783

9

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Gan J, Ma S, Zhang D. Gan J, et al. Among authors: ma s. Drug Metab Rev. 2016 Nov;48(4):473-501. doi: 10.1080/03602532.2016.1225756. Epub 2016 Sep 20. Drug Metab Rev. 2016. PMID: 27533622 Review.

10

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.

Takahashi RH, Halladay JS, Siu M, Chen Y, Hop CE, Khojasteh SC, Ma S. Takahashi RH, et al. Among authors: ma s. Drug Metab Dispos. 2017 May;45(5):430-440. doi: 10.1124/dmd.116.074336. Epub 2017 Feb 10. Drug Metab Dispos. 2017. PMID: 28188299

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