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Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction.
Wong SG, Fan PW, Subramanian R, Tonn GR, Henne KR, Johnson MG, Tadano Lohr M, Wong BK. Wong SG, et al. Among authors: fan pw. Drug Metab Dispos. 2010 May;38(5):841-50. doi: 10.1124/dmd.109.031344. Epub 2010 Jan 25. Drug Metab Dispos. 2010. PMID: 20100816
Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.
Le H, Fan PW, Wong S, Ma S, Driscoll JP, Hop CE, Cyrus Khojasteh S. Le H, et al. Among authors: fan pw. Drug Metab Lett. 2016;10(2):136-43. doi: 10.2174/1872312810666160427104954. Drug Metab Lett. 2016. PMID: 27117606
Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.
Zhang D, Pillow TH, Ma Y, Cruz-Chuh JD, Kozak KR, Sadowsky JD, Lewis Phillips GD, Guo J, Darwish M, Fan P, Chen J, He C, Wang T, Yao H, Xu Z, Chen J, Wai J, Pei Z, Hop CE, Khojasteh SC, Dragovich PS. Zhang D, et al. ACS Med Chem Lett. 2016 Aug 26;7(11):988-993. doi: 10.1021/acsmedchemlett.6b00233. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882196 Free PMC article.
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis Phillips GD, Vollmar BS, Sadowsky JD, Vandlen R, Wei B, Su D, Fan P, Dragovich PS, Khojasteh SC, Hop CECA, Pillow TH. Zhang D, et al. Bioconjug Chem. 2018 Feb 21;29(2):267-274. doi: 10.1021/acs.bioconjchem.7b00576. Epub 2018 Feb 7. Bioconjug Chem. 2018. PMID: 29369629
59 results