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Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.
Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA. Forkuo GS, et al. Among authors: cook jm. Mol Pharm. 2016 Jun 6;13(6):2026-38. doi: 10.1021/acs.molpharmaceut.6b00159. Epub 2016 May 10. Mol Pharm. 2016. PMID: 27120014 Free PMC article.
Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.
Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM. Huang Q, et al. Among authors: cook jm. J Med Chem. 1998 Oct 8;41(21):4130-42. doi: 10.1021/jm980317y. J Med Chem. 1998. PMID: 9767648
An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.
Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. Clayton T, et al. Among authors: cook jm. Curr Med Chem. 2007;14(26):2755-75. doi: 10.2174/092986707782360097. Curr Med Chem. 2007. PMID: 18045122 Review.
627 results