Park H - Search Results

1

Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.

Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven CM, Kim C, Spencer B, Adame A, Park H, Dodge JC, Cheng SH, Shihabuddin LS, Masliah E, Sardi SP. Rockenstein E, et al. Among authors: park h. Hum Mol Genet. 2016 Jul 1;25(13):2645-2660. doi: 10.1093/hmg/ddw124. Epub 2016 Apr 28. Hum Mol Genet. 2016. PMID: 27126635 Free PMC article.

2

Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.

Sardi SP, Viel C, Clarke J, Treleaven CM, Richards AM, Park H, Olszewski MA, Dodge JC, Marshall J, Makino E, Wang B, Sidman RL, Cheng SH, Shihabuddin LS. Sardi SP, et al. Among authors: park h. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2699-2704. doi: 10.1073/pnas.1616152114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223512 Free PMC article.

3

Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.

Viel C, Clarke J, Kayatekin C, Richards AM, Chiang MSR, Park H, Wang B, Shihabuddin LS, Sardi SP. Viel C, et al. Among authors: park h. Sci Rep. 2021 Oct 22;11(1):20945. doi: 10.1038/s41598-021-00404-5. Sci Rep. 2021. PMID: 34686711 Free PMC article.

4

Substrate reduction therapy using Genz-667161 reduces levels of pathogenic components in a mouse model of neuronopathic forms of Gaucher disease.

Blumenreich S, Yaacobi C, Vardi A, Barav OB, Vitner EB, Park H, Wang B, Cheng SH, Sardi SP, Futerman AH. Blumenreich S, et al. Among authors: park h. J Neurochem. 2021 Mar;156(5):692-701. doi: 10.1111/jnc.15136. Epub 2020 Sep 12. J Neurochem. 2021. PMID: 32743826 Free article.

5

CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease.

Marshall J, Sun Y, Bangari DS, Budman E, Park H, Nietupski JB, Allaire A, Cromwell MA, Wang B, Grabowski GA, Leonard JP, Cheng SH. Marshall J, et al. Among authors: park h. Mol Ther. 2016 Jun;24(6):1019-1029. doi: 10.1038/mt.2016.53. Epub 2016 Mar 7. Mol Ther. 2016. PMID: 26948439 Free PMC article.

6

The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α-Synuclein in PD_GBA.

Lerche S, Schulte C, Wurster I, Machetanz G, Roeben B, Zimmermann M, Deuschle C, Hauser AK, Böhringer J, Krägeloh-Mann I, Waniek K, Lachmann I, Petterson XT, Chiang R, Park H, Wang B, Liepelt-Scarfone I, Maetzler W, Galasko D, Scherzer CR, Gasser T, Mielke MM, Hutten SJ, Mollenhauer B, Sardi SP, Berg D, Brockmann K. Lerche S, et al. Among authors: park h. Mov Disord. 2021 May;36(5):1216-1228. doi: 10.1002/mds.28472. Epub 2021 Feb 6. Mov Disord. 2021. PMID: 33547828

7

Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson's disease enrolled in PPMI.

Huh YE, Park H, Chiang MSR, Tuncali I, Liu G, Locascio JJ, Shirvan J, Hutten SJ, Rotunno MS, Viel C, Shihabuddin LS, Wang B, Sardi SP, Scherzer CR. Huh YE, et al. Among authors: park h. NPJ Parkinsons Dis. 2021 Nov 22;7(1):102. doi: 10.1038/s41531-021-00241-3. NPJ Parkinsons Dis. 2021. PMID: 34811369 Free PMC article.

8

A novel brain-penetrant oral UGT8 inhibitor decreases in vivo galactosphingolipid biosynthesis in murine Krabbe disease.

Zaccariotto E, Cachón-González MB, Wang B, Lim S, Hirth B, Park H, Fezoui M, Sardi SP, Mason P, Barker RH Jr, Cox TM. Zaccariotto E, et al. Among authors: park h. Biomed Pharmacother. 2022 May;149:112808. doi: 10.1016/j.biopha.2022.112808. Epub 2022 Mar 12. Biomed Pharmacother. 2022. PMID: 35290889 Free article.

9

Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity.

Marshall J, Nietupski JB, Park H, Cao J, Bangari DS, Silvescu C, Wilper T, Randall K, Tietz D, Wang B, Ying X, Leonard JP, Cheng SH. Marshall J, et al. Among authors: park h. Mol Ther. 2019 Aug 7;27(8):1495-1506. doi: 10.1016/j.ymthe.2019.05.018. Epub 2019 Jun 4. Mol Ther. 2019. PMID: 31208914 Free PMC article.

10

Correction of cilia structure and function alleviates multi-organ pathology in Bardet-Biedl syndrome mice.

Husson H, Bukanov NO, Moreno S, Smith MM, Richards B, Zhu C, Picariello T, Park H, Wang B, Natoli TA, Smith LA, Zanotti S, Russo RJ, Madden SL, Klinger KW, Modur V, Ibraghimov-Beskrovnaya O. Husson H, et al. Among authors: park h. Hum Mol Genet. 2020 Aug 29;29(15):2508-2522. doi: 10.1093/hmg/ddaa138. Hum Mol Genet. 2020. PMID: 32620959 Free PMC article.

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