Sardi SP - Search Results

1

Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.

Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven CM, Kim C, Spencer B, Adame A, Park H, Dodge JC, Cheng SH, Shihabuddin LS, Masliah E, Sardi SP. Rockenstein E, et al. Among authors: sardi sp. Hum Mol Genet. 2016 Jul 1;25(13):2645-2660. doi: 10.1093/hmg/ddw124. Epub 2016 Apr 28. Hum Mol Genet. 2016. PMID: 27126635 Free PMC article.

2

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

Passini MA, Bu J, Roskelley EM, Richards AM, Sardi SP, O'Riordan CR, Klinger KW, Shihabuddin LS, Cheng SH. Passini MA, et al. Among authors: sardi sp. J Clin Invest. 2010 Apr;120(4):1253-64. doi: 10.1172/JCI41615. Epub 2010 Mar 15. J Clin Invest. 2010. PMID: 20234094 Free PMC article.

3

Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders.

Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS. Salegio EA, et al. Among authors: sardi sp. Hum Gene Ther. 2010 Sep;21(9):1093-103. doi: 10.1089/hum.2010.040. Hum Gene Ther. 2010. PMID: 20408734 Free PMC article.

4

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy.

Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH. Passini MA, et al. Among authors: sardi sp. Sci Transl Med. 2011 Mar 2;3(72):72ra18. doi: 10.1126/scitranslmed.3001777. Sci Transl Med. 2011. PMID: 21368223 Free PMC article.

5

Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

Cullen V, Sardi SP, Ng J, Xu YH, Sun Y, Tomlinson JJ, Kolodziej P, Kahn I, Saftig P, Woulfe J, Rochet JC, Glicksman MA, Cheng SH, Grabowski GA, Shihabuddin LS, Schlossmacher MG. Cullen V, et al. Among authors: sardi sp. Ann Neurol. 2011 Jun;69(6):940-53. doi: 10.1002/ana.22400. Epub 2011 Apr 6. Ann Neurol. 2011. PMID: 21472771

6

CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy.

Sardi SP, Clarke J, Kinnecom C, Tamsett TJ, Li L, Stanek LM, Passini MA, Grabowski GA, Schlossmacher MG, Sidman RL, Cheng SH, Shihabuddin LS. Sardi SP, et al. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12101-6. doi: 10.1073/pnas.1108197108. Epub 2011 Jul 5. Proc Natl Acad Sci U S A. 2011. PMID: 21730160 Free PMC article.

7

Mutant GBA1 expression and synucleinopathy risk: first insights from cellular and mouse models.

Sardi SP, Singh P, Cheng SH, Shihabuddin LS, Schlossmacher MG. Sardi SP, et al. Neurodegener Dis. 2012;10(1-4):195-202. doi: 10.1159/000335038. Epub 2012 Feb 9. Neurodegener Dis. 2012. PMID: 22327140 Review.

8

Gene transfer to the CNS is efficacious in immune-primed mice harboring physiologically relevant titers of anti-AAV antibodies.

Treleaven CM, Tamsett TJ, Bu J, Fidler JA, Sardi SP, Hurlbut GD, Woodworth LA, Cheng SH, Passini MA, Shihabuddin LS, Dodge JC. Treleaven CM, et al. Among authors: sardi sp. Mol Ther. 2012 Sep;20(9):1713-23. doi: 10.1038/mt.2012.114. Epub 2012 Jun 26. Mol Ther. 2012. PMID: 22735381 Free PMC article.

9

Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.

Sardi SP, Clarke J, Viel C, Chan M, Tamsett TJ, Treleaven CM, Bu J, Sweet L, Passini MA, Dodge JC, Yu WH, Sidman RL, Cheng SH, Shihabuddin LS. Sardi SP, et al. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3537-42. doi: 10.1073/pnas.1220464110. Epub 2013 Jan 7. Proc Natl Acad Sci U S A. 2013. PMID: 23297226 Free PMC article.

10

Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease.

Stanek LM, Sardi SP, Mastis B, Richards AR, Treleaven CM, Taksir T, Misra K, Cheng SH, Shihabuddin LS. Stanek LM, et al. Among authors: sardi sp. Hum Gene Ther. 2014 May;25(5):461-74. doi: 10.1089/hum.2013.200. Epub 2014 Mar 21. Hum Gene Ther. 2014. PMID: 24484067 Free PMC article.

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