Sandström A - Search Results

1

Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease.

Belfrage AK, Abdurakhmanov E, Kerblom E, Brandt P, Oshalim A, Gising J, Skogh A, Neyts J, Danielson UH, Sandström A. Belfrage AK, et al. Among authors: sandstrom a. Bioorg Med Chem. 2016 Jun 15;24(12):2603-20. doi: 10.1016/j.bmc.2016.03.066. Epub 2016 Apr 8. Bioorg Med Chem. 2016. PMID: 27160057

2

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.

Ortqvist P, Peterson SD, Kerblom E, Gossas T, Sabnis YA, Fransson R, Lindeberg G, Helena Danielson U, Karlén A, Sandström A. Ortqvist P, et al. Among authors: sandstrom a. Bioorg Med Chem. 2007 Feb 1;15(3):1448-74. doi: 10.1016/j.bmc.2006.11.003. Epub 2006 Nov 6. Bioorg Med Chem. 2007. PMID: 17113777

3

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.

Rönn R, Gossas T, Sabnis YA, Daoud H, Kerblom E, Danielson UH, Sandström A. Rönn R, et al. Among authors: sandstrom a. Bioorg Med Chem. 2007 Jun 15;15(12):4057-68. doi: 10.1016/j.bmc.2007.03.089. Epub 2007 Apr 4. Bioorg Med Chem. 2007. PMID: 17449253

4

Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3.

Poliakov A, Sandström A, Akerblom E, Danielson UH. Poliakov A, et al. Among authors: sandstrom a. J Enzyme Inhib Med Chem. 2007 Apr;22(2):191-9. doi: 10.1080/14756360601072916. J Enzyme Inhib Med Chem. 2007. PMID: 17518346 Free article.

5

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3.

Dahl G, Sandström A, Akerblom E, Danielson UH. Dahl G, et al. Among authors: sandstrom a. Antivir Ther. 2007;12(5):733-40. Antivir Ther. 2007. PMID: 17713156

6

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.

Dahl G, Sandström A, Akerblom E, Danielson UH. Dahl G, et al. Among authors: sandstrom a. FEBS J. 2007 Nov;274(22):5979-86. doi: 10.1111/j.1742-4658.2007.06120.x. Epub 2007 Oct 19. FEBS J. 2007. PMID: 17949436 Free article.

7

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.

Rönn R, Lampa A, Peterson SD, Gossas T, Akerblom E, Danielson UH, Karlén A, Sandström A. Rönn R, et al. Among authors: sandstrom a. Bioorg Med Chem. 2008 Mar 15;16(6):2955-67. doi: 10.1016/j.bmc.2007.12.041. Epub 2007 Dec 27. Bioorg Med Chem. 2008. PMID: 18194867

8

Beta-amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors.

Nurbo J, Peterson SD, Dahl G, Helena Danielson U, Karlén A, Sandström A. Nurbo J, et al. Among authors: sandstrom a. Bioorg Med Chem. 2008 May 15;16(10):5590-605. doi: 10.1016/j.bmc.2008.04.005. Epub 2008 Apr 6. Bioorg Med Chem. 2008. PMID: 18434166

9

New developments in the discovery of agents to treat hepatitis C.

Rönn R, Sandström A. Rönn R, et al. Among authors: sandstrom a. Curr Top Med Chem. 2008;8(7):533-62. doi: 10.2174/156802608783955647. Curr Top Med Chem. 2008. PMID: 18473882 Review.

10

A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones.

Gising J, Ortqvist P, Sandström A, Larhed M. Gising J, et al. Among authors: sandstrom a. Org Biomol Chem. 2009 Jul 7;7(13):2809-15. doi: 10.1039/b905501k. Epub 2009 May 27. Org Biomol Chem. 2009. PMID: 19532999

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