Warrilow AG - Search Results

1

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Warrilow AG, Parker JE, Price CL, Nes WD, Garvey EP, Hoekstra WJ, Schotzinger RJ, Kelly DE, Kelly SL. Warrilow AG, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8. doi: 10.1128/AAC.00349-16. Print 2016 Aug. Antimicrob Agents Chemother. 2016. PMID: 27161631 Free PMC article.

2

The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.

Warrilow AG, Hull CM, Parker JE, Garvey EP, Hoekstra WJ, Moore WR, Schotzinger RJ, Kelly DE, Kelly SL. Warrilow AG, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. doi: 10.1128/AAC.03707-14. Epub 2014 Sep 15. Antimicrob Agents Chemother. 2014. PMID: 25224009 Free PMC article.

3

Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.

Warrilow AG, Parker JE, Kelly DE, Kelly SL. Warrilow AG, et al. Antimicrob Agents Chemother. 2013 Mar;57(3):1352-60. doi: 10.1128/AAC.02067-12. Epub 2012 Dec 28. Antimicrob Agents Chemother. 2013. PMID: 23274672 Free PMC article.

4

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions.

Warrilow AG, Nishimoto AT, Parker JE, Price CL, Flowers SA, Kelly DE, Rogers PD, Kelly SL. Warrilow AG, et al. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02586-18. doi: 10.1128/AAC.02586-18. Print 2019 May. Antimicrob Agents Chemother. 2019. PMID: 30783005 Free PMC article.

5

Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.

Warrilow AG, Jackson CJ, Parker JE, Marczylo TH, Kelly DE, Lamb DC, Kelly SL. Warrilow AG, et al. Antimicrob Agents Chemother. 2009 Mar;53(3):1157-64. doi: 10.1128/AAC.01237-08. Epub 2008 Dec 15. Antimicrob Agents Chemother. 2009. PMID: 19075057 Free PMC article.

6

A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL. Martel CM, et al. Among authors: warrilow ag. Antimicrob Agents Chemother. 2010 Sep;54(9):3578-83. doi: 10.1128/AAC.00303-10. Epub 2010 Jun 14. Antimicrob Agents Chemother. 2010. PMID: 20547793 Free PMC article.

7

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL. Warrilow AG, et al. Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12. Antimicrob Agents Chemother. 2010. PMID: 20625155 Free PMC article.

8

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

Warrilow AG, Melo N, Martel CM, Parker JE, Nes WD, Kelly SL, Kelly DE. Warrilow AG, et al. Antimicrob Agents Chemother. 2010 Oct;54(10):4225-34. doi: 10.1128/AAC.00316-10. Epub 2010 Jul 26. Antimicrob Agents Chemother. 2010. PMID: 20660663 Free PMC article.

9

Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Rolley N, Kelly DE, Kelly SL. Martel CM, et al. Among authors: warrilow ag. Antimicrob Agents Chemother. 2010 Nov;54(11):4527-33. doi: 10.1128/AAC.00348-10. Epub 2010 Aug 23. Antimicrob Agents Chemother. 2010. PMID: 20733039 Free PMC article.

10

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.

Martel CM, Parker JE, Warrilow AG, Rolley NJ, Kelly SL, Kelly DE. Martel CM, et al. Among authors: warrilow ag. Antimicrob Agents Chemother. 2010 Nov;54(11):4920-3. doi: 10.1128/AAC.00349-10. Epub 2010 Aug 23. Antimicrob Agents Chemother. 2010. PMID: 20733045 Free PMC article.

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