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Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers.
Gray MJ, Gong J, Hatch MM, Nguyen V, Hughes CC, Hutchins JT, Freimark BD. Gray MJ, et al. Among authors: freimark bd. Breast Cancer Res. 2016 May 11;18(1):50. doi: 10.1186/s13058-016-0708-2. Breast Cancer Res. 2016. PMID: 27169467 Free PMC article.
Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression.
Kasikara C, Kumar S, Kimani S, Tsou WI, Geng K, Davra V, Sriram G, Devoe C, Nguyen KN, Antes A, Krantz A, Rymarczyk G, Wilczynski A, Empig C, Freimark B, Gray M, Schlunegger K, Hutchins J, Kotenko SV, Birge RB. Kasikara C, et al. Mol Cancer Res. 2017 Jun;15(6):753-764. doi: 10.1158/1541-7786.MCR-16-0350. Epub 2017 Feb 9. Mol Cancer Res. 2017. PMID: 28184013 Free PMC article.
Rapid vascular regrowth in tumors after reversal of VEGF inhibition.
Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T, Yao VJ, Inai T, Brooks P, Freimark B, Shalinsky DR, Hu-Lowe DD, McDonald DM. Mancuso MR, et al. J Clin Invest. 2006 Oct;116(10):2610-21. doi: 10.1172/JCI24612. J Clin Invest. 2006. PMID: 17016557 Free PMC article.
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