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Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.
Otterdal K, Portillo A, Astrup E, Ludviksen JK, Schjalm C, Raoult D, Olano JP, Halvorsen B, Oteo JA, Aukrust P, Mollnes TE, Nilsson PH. Otterdal K, et al. Among authors: olano jp. Clin Microbiol Infect. 2016 Aug;22(8):734.e1-6. doi: 10.1016/j.cmi.2016.05.010. Epub 2016 May 20. Clin Microbiol Infect. 2016. PMID: 27217049 Free article.
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