Liekens S - Search Results

1

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S. Canela MD, et al. Among authors: liekens s. Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527. Oncotarget. 2017. PMID: 27224920 Free PMC article.

2

Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.

Canela MD, Pérez-Pérez MJ, Noppen S, Sáez-Calvo G, Díaz JF, Camarasa MJ, Liekens S, Priego EM. Canela MD, et al. Among authors: liekens s. J Med Chem. 2014 May 22;57(10):3924-38. doi: 10.1021/jm401939g. Epub 2014 May 9. J Med Chem. 2014. PMID: 24773591 Free article.

3

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.

Pérez-Pérez MJ, Priego EM, Bueno O, Martins MS, Canela MD, Liekens S. Pérez-Pérez MJ, et al. Among authors: liekens s. J Med Chem. 2016 Oct 13;59(19):8685-8711. doi: 10.1021/acs.jmedchem.6b00463. Epub 2016 Jun 27. J Med Chem. 2016. PMID: 27348355 Free article.

4

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.

Bueno O, Tobajas G, Quesada E, Estévez-Gallego J, Noppen S, Camarasa MJ, Díaz JF, Liekens S, Priego EM, Pérez-Pérez MJ. Bueno O, et al. Among authors: liekens s. Eur J Med Chem. 2018 Mar 25;148:337-348. doi: 10.1016/j.ejmech.2018.02.019. Epub 2018 Feb 10. Eur J Med Chem. 2018. PMID: 29471122

5

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.

Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM. Bueno O, et al. Among authors: liekens s. Sci Rep. 2018 Mar 9;8(1):4242. doi: 10.1038/s41598-018-22382-x. Sci Rep. 2018. PMID: 29523799 Free PMC article.

6

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.

Bueno O, Gargantilla M, Estévez-Gallego J, Martins S, Díaz JF, Camarasa MJ, Liekens S, Pérez-Pérez MJ, Priego EM. Bueno O, et al. Among authors: liekens s. Eur J Med Chem. 2019 Jun 1;171:195-208. doi: 10.1016/j.ejmech.2019.03.045. Epub 2019 Mar 21. Eur J Med Chem. 2019. PMID: 30921759

7

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

Pérez-Pérez MJ, Priego EM, Hernández AI, Camarasa MJ, Balzarini J, Liekens S. Pérez-Pérez MJ, et al. Among authors: liekens s. Mini Rev Med Chem. 2005 Dec;5(12):1113-23. doi: 10.2174/138955705774933301. Mini Rev Med Chem. 2005. PMID: 16375757 Review.

8

5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis.

Liekens S, Bronckaers A, Hernández AI, Priego EM, Casanova E, Camarasa MJ, Pérez-Pérez MJ, Balzarini J. Liekens S, et al. Mol Pharmacol. 2006 Aug;70(2):501-9. doi: 10.1124/mol.105.021188. Epub 2006 May 4. Mol Pharmacol. 2006. PMID: 16675660

9

5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.

Casanova E, Hernandez AI, Priego EM, Liekens S, Camarasa MJ, Balzarini J, Pérez-Pérez MJ. Casanova E, et al. Among authors: liekens s. J Med Chem. 2006 Sep 7;49(18):5562-70. doi: 10.1021/jm0605379. J Med Chem. 2006. PMID: 16942029

10

Synthesis and antiproliferative activity of 6-phenylaminopurines.

Canela MD, Liekens S, Camarasa MJ, Priego EM, Pérez-Pérez MJ. Canela MD, et al. Among authors: liekens s. Eur J Med Chem. 2014 Nov 24;87:421-8. doi: 10.1016/j.ejmech.2014.09.093. Epub 2014 Sep 30. Eur J Med Chem. 2014. PMID: 25282265

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