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The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.
Fang D, Gan H, Lee JH, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu RM, Westendorf JJ, Zhang Z. Fang D, et al. Among authors: westendorf jj. Science. 2016 Jun 10;352(6291):1344-8. doi: 10.1126/science.aae0065. Epub 2016 May 26. Science. 2016. PMID: 27229140 Free PMC article.
p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation.
Jensen ED, Niu L, Caretti G, Nicol SM, Teplyuk N, Stein GS, Sartorelli V, van Wijnen AJ, Fuller-Pace FV, Westendorf JJ. Jensen ED, et al. Among authors: westendorf jj. J Cell Biochem. 2008 Apr 1;103(5):1438-51. doi: 10.1002/jcb.21526. J Cell Biochem. 2008. PMID: 17960593
The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss.
Pratap J, Akech J, Wixted JJ, Szabo G, Hussain S, McGee-Lawrence ME, Li X, Bedard K, Dhillon RJ, van Wijnen AJ, Stein JL, Stein GS, Westendorf JJ, Lian JB. Pratap J, et al. Among authors: westendorf jj. Mol Cancer Ther. 2010 Dec;9(12):3210-20. doi: 10.1158/1535-7163.MCT-10-0572. Mol Cancer Ther. 2010. PMID: 21159607 Free PMC article.
Hdac-mediated control of endochondral and intramembranous ossification.
Bradley EW, McGee-Lawrence ME, Westendorf JJ. Bradley EW, et al. Among authors: westendorf jj. Crit Rev Eukaryot Gene Expr. 2011;21(2):101-13. doi: 10.1615/critreveukargeneexpr.v21.i2.10. Crit Rev Eukaryot Gene Expr. 2011. PMID: 22077150 Free PMC article. Review.
Histone deacetylase 3 is required for maintenance of bone mass during aging.
McGee-Lawrence ME, Bradley EW, Dudakovic A, Carlson SW, Ryan ZC, Kumar R, Dadsetan M, Yaszemski MJ, Chen Q, An KN, Westendorf JJ. McGee-Lawrence ME, et al. Among authors: westendorf jj. Bone. 2013 Jan;52(1):296-307. doi: 10.1016/j.bone.2012.10.015. Epub 2012 Oct 18. Bone. 2013. PMID: 23085085 Free PMC article.
Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice.
McGee-Lawrence ME, Li X, Bledsoe KL, Wu H, Hawse JR, Subramaniam M, Razidlo DF, Stensgard BA, Stein GS, van Wijnen AJ, Lian JB, Hsu W, Westendorf JJ. McGee-Lawrence ME, et al. Among authors: westendorf jj. J Biol Chem. 2013 Feb 22;288(8):5291-302. doi: 10.1074/jbc.M112.414995. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23300083 Free PMC article.
171 results