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DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas.
Jeyapalan JN, Doctor GT, Jones TA, Alberman SN, Tep A, Haria CM, Schwalbe EC, Morley IC, Hill AA, LeCain M, Ottaviani D, Clifford SC, Qaddoumi I, Tatevossian RG, Ellison DW, Sheer D. Jeyapalan JN, et al. Among authors: schwalbe ec. Acta Neuropathol Commun. 2016 May 27;4(1):54. doi: 10.1186/s40478-016-0323-6. Acta Neuropathol Commun. 2016. PMID: 27229157 Free PMC article.
Rapid diagnosis of medulloblastoma molecular subgroups.
Schwalbe EC, Lindsey JC, Straughton D, Hogg TL, Cole M, Megahed H, Ryan SL, Lusher ME, Taylor MD, Gilbertson RJ, Ellison DW, Bailey S, Clifford SC. Schwalbe EC, et al. Clin Cancer Res. 2011 Apr 1;17(7):1883-94. doi: 10.1158/1078-0432.CCR-10-2210. Epub 2011 Feb 16. Clin Cancer Res. 2011. PMID: 21325292 Free PMC article.
TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas.
Lindsey JC, Hill RM, Megahed H, Lusher ME, Schwalbe EC, Cole M, Hogg TL, Gilbertson RJ, Ellison DW, Bailey S, Clifford SC. Lindsey JC, et al. Among authors: schwalbe ec. J Clin Oncol. 2011 Apr 20;29(12):e344-6; author reply e347-8. doi: 10.1200/JCO.2010.33.8590. Epub 2011 Feb 28. J Clin Oncol. 2011. PMID: 21357788 No abstract available.
Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.
Jeyapalan JN, Noor DA, Lee SH, Tan CL, Appleby VA, Kilday JP, Palmer RD, Schwalbe EC, Clifford SC, Walker DA, Murray MJ, Coleman N, Nicholson JC, Scotting PJ. Jeyapalan JN, et al. Among authors: schwalbe ec. Br J Cancer. 2011 Aug 9;105(4):575-85. doi: 10.1038/bjc.2011.218. Epub 2011 Jun 28. Br J Cancer. 2011. PMID: 21712824 Free PMC article.
Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death.
Rogers HA, Kilday JP, Mayne C, Ward J, Adamowicz-Brice M, Schwalbe EC, Clifford SC, Coyle B, Grundy RG. Rogers HA, et al. Among authors: schwalbe ec. Acta Neuropathol. 2012 May;123(5):711-25. doi: 10.1007/s00401-011-0904-1. Epub 2011 Nov 23. Acta Neuropathol. 2012. PMID: 22109108 Free PMC article.
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma.
Ryan SL, Schwalbe EC, Cole M, Lu Y, Lusher ME, Megahed H, O'Toole K, Nicholson SL, Bognar L, Garami M, Hauser P, Korshunov A, Pfister SM, Williamson D, Taylor RE, Ellison DW, Bailey S, Clifford SC. Ryan SL, et al. Among authors: schwalbe ec. Acta Neuropathol. 2012 Apr;123(4):501-13. doi: 10.1007/s00401-011-0923-y. Epub 2011 Dec 3. Acta Neuropathol. 2012. PMID: 22139329
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies.
Schwalbe EC, Williamson D, Lindsey JC, Hamilton D, Ryan SL, Megahed H, Garami M, Hauser P, Dembowska-Baginska B, Perek D, Northcott PA, Taylor MD, Taylor RE, Ellison DW, Bailey S, Clifford SC. Schwalbe EC, et al. Acta Neuropathol. 2013 Mar;125(3):359-71. doi: 10.1007/s00401-012-1077-2. Epub 2013 Jan 5. Acta Neuropathol. 2013. PMID: 23291781 Free PMC article.
Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types.
Schwalbe EC, Hayden JT, Rogers HA, Miller S, Lindsey JC, Hill RM, Nicholson SL, Kilday JP, Adamowicz-Brice M, Storer L, Jacques TS, Robson K, Lowe J, Williamson D, Grundy RG, Bailey S, Clifford SC. Schwalbe EC, et al. Acta Neuropathol. 2013 Dec;126(6):943-6. doi: 10.1007/s00401-013-1206-6. Epub 2013 Nov 9. Acta Neuropathol. 2013. PMID: 24212602 Free PMC article. No abstract available.
TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.
Lindsey JC, Schwalbe EC, Potluri S, Bailey S, Williamson D, Clifford SC. Lindsey JC, et al. Among authors: schwalbe ec. Acta Neuropathol. 2014 Feb;127(2):307-9. doi: 10.1007/s00401-013-1225-3. Epub 2013 Dec 12. Acta Neuropathol. 2014. PMID: 24337442 Free PMC article. No abstract available.
67 results