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114 results

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Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.
Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, Ramón González-Porras J, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J. Lozano ML, et al. Among authors: paul ds. Blood. 2016 Sep 1;128(9):1282-9. doi: 10.1182/blood-2015-11-683102. Epub 2016 May 27. Blood. 2016. PMID: 27235135 Free PMC article. Clinical Trial.
RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W. Stefanini L, et al. Among authors: paul ds. J Clin Invest. 2015 Apr;125(4):1419-32. doi: 10.1172/JCI77993. Epub 2015 Feb 23. J Clin Invest. 2015. PMID: 25705885 Free PMC article.
Rap1 and its effector RIAM are required for lymphocyte trafficking.
Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR. Su W, et al. Among authors: paul ds. Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31. Blood. 2015. PMID: 26324702 Free PMC article.
CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.
Boulaftali Y, Owens AP 3rd, Beale A, Piatt R, Casari C, Lee RH, Conley PB, Paul DS, Mackman N, Bergmeier W. Boulaftali Y, et al. Among authors: paul ds. Arterioscler Thromb Vasc Biol. 2016 May;36(5):792-9. doi: 10.1161/ATVBAHA.115.306347. Epub 2016 Mar 17. Arterioscler Thromb Vasc Biol. 2016. PMID: 26988592 Free PMC article.
The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.
Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I. Battram AM, et al. Among authors: paul ds. J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30. J Biol Chem. 2017. PMID: 27903653 Free PMC article.
Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.
Sevivas T, Bastida JM, Paul DS, Caparros E, Palma-Barqueros V, Coucelo M, Marques D, Ferrer-Marín F, González-Porras JR, Vicente V, Hernández-Rivas JM, Watson SP, Lozano ML, Bergmeier W, Rivera J. Sevivas T, et al. Among authors: paul ds. Platelets. 2018 Mar;29(2):192-195. doi: 10.1080/09537104.2017.1336214. Epub 2017 Aug 1. Platelets. 2018. PMID: 28762304 Free PMC article.
114 results