Sondek J - Search Results

1

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.

Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, Ramón González-Porras J, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J. Lozano ML, et al. Among authors: sondek j. Blood. 2016 Sep 1;128(9):1282-9. doi: 10.1182/blood-2015-11-683102. Epub 2016 May 27. Blood. 2016. PMID: 27235135 Free PMC article. Clinical Trial.

2

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation.

Ren J, Cook AA, Bergmeier W, Sondek J. Ren J, et al. Among authors: sondek j. Biochem Biophys Res Commun. 2016 May 20;474(1):193-198. doi: 10.1016/j.bbrc.2016.04.100. Epub 2016 Apr 21. Biochem Biophys Res Commun. 2016. PMID: 27107697 Free PMC article.

3

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI.

Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W. Cook AA, et al. Among authors: sondek j. J Biol Chem. 2018 Jun 1;293(22):8521-8529. doi: 10.1074/jbc.RA118.002712. Epub 2018 Apr 5. J Biol Chem. 2018. PMID: 29622678 Free PMC article.

4

Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation.

Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J. Rossman KL, et al. Among authors: sondek j. J Biol Chem. 2003 May 16;278(20):18393-400. doi: 10.1074/jbc.M300127200. Epub 2003 Mar 13. J Biol Chem. 2003. PMID: 12637522 Free article.

5

Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Yohe ME, et al. Among authors: sondek j. J Biol Chem. 2007 May 4;282(18):13813-23. doi: 10.1074/jbc.M700185200. Epub 2007 Mar 2. J Biol Chem. 2007. PMID: 17337446 Free article.

6

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.

Chhatriwala MK, Betts L, Worthylake DK, Sondek J. Chhatriwala MK, et al. Among authors: sondek j. J Mol Biol. 2007 May 18;368(5):1307-20. doi: 10.1016/j.jmb.2007.02.060. Epub 2007 Feb 22. J Mol Biol. 2007. PMID: 17391702 Free PMC article.

7

Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton.

Shock DD, Naik UP, Brittain JE, Alahari SK, Sondek J, Parise LV. Shock DD, et al. Among authors: sondek j. Biochem J. 1999 Sep 15;342 Pt 3(Pt 3):729-35. Biochem J. 1999. PMID: 10477286 Free PMC article.

8

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

Worthylake DK, Rossman KL, Sondek J. Worthylake DK, et al. Among authors: sondek j. Nature. 2000 Dec 7;408(6813):682-8. doi: 10.1038/35047014. Nature. 2000. PMID: 11130063

9

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

Karnoub AE, Worthylake DK, Rossman KL, Pruitt WM, Campbell SL, Sondek J, Der CJ. Karnoub AE, et al. Among authors: sondek j. Nat Struct Biol. 2001 Dec;8(12):1037-41. doi: 10.1038/nsb719. Nat Struct Biol. 2001. PMID: 11685227

10

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J. Rossman KL, et al. Among authors: sondek j. EMBO J. 2002 Mar 15;21(6):1315-26. doi: 10.1093/emboj/21.6.1315. EMBO J. 2002. PMID: 11889037 Free PMC article.

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