Khosla C - Search Results

1

Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.

Klaus M, Ostrowski MP, Austerjost J, Robbins T, Lowry B, Cane DE, Khosla C. Klaus M, et al. Among authors: khosla c. J Biol Chem. 2016 Jul 29;291(31):16404-15. doi: 10.1074/jbc.M116.730531. Epub 2016 May 31. J Biol Chem. 2016. PMID: 27246853 Free PMC article.

2

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.

Pieper R, Luo G, Cane DE, Khosla C. Pieper R, et al. Among authors: khosla c. Nature. 1995 Nov 16;378(6554):263-6. doi: 10.1038/378263a0. Nature. 1995. PMID: 7477343

3

Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host.

Cane DE, Luo G, Khosla C, Kao CM, Katz L. Cane DE, et al. Among authors: khosla c. J Antibiot (Tokyo). 1995 Jul;48(7):647-51. doi: 10.7164/antibiotics.48.647. J Antibiot (Tokyo). 1995. PMID: 7649863 Free article.

4

Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.

Pieper R, Ebert-Khosla S, Cane D, Khosla C. Pieper R, et al. Among authors: khosla c. Biochemistry. 1996 Feb 20;35(7):2054-60. doi: 10.1021/bi952860b. Biochemistry. 1996. PMID: 8652546

5

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.

Kao CM, Pieper R, Cane DE, Khosla C. Kao CM, et al. Among authors: khosla c. Biochemistry. 1996 Sep 24;35(38):12363-8. doi: 10.1021/bi9616312. Biochemistry. 1996. PMID: 8823171

6

Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase.

Luo G, Pieper R, Rosa A, Khosla C, Cane DE. Luo G, et al. Among authors: khosla c. Bioorg Med Chem. 1996 Jul;4(7):995-9. doi: 10.1016/0968-0896(96)00096-x. Bioorg Med Chem. 1996. PMID: 8831969

7

A functional chimeric modular polyketide synthase generated via domain replacement.

Bedford D, Jacobsen JR, Luo G, Cane DE, Khosla C. Bedford D, et al. Among authors: khosla c. Chem Biol. 1996 Oct;3(10):827-31. doi: 10.1016/s1074-5521(96)90068-x. Chem Biol. 1996. PMID: 8939701

8

6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.

Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE. Tsukamoto N, et al. Among authors: khosla c. Biochemistry. 1996 Dec 3;35(48):15244-8. doi: 10.1021/bi961972f. Biochemistry. 1996. PMID: 8952473

9

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.

Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C. Pieper R, et al. Among authors: khosla c. Biochemistry. 1997 Feb 18;36(7):1846-51. doi: 10.1021/bi962324z. Biochemistry. 1997. PMID: 9048569

10

Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits.

Zawada RJ, Khosla C. Zawada RJ, et al. Among authors: khosla c. J Biol Chem. 1997 Jun 27;272(26):16184-8. doi: 10.1074/jbc.272.26.16184. J Biol Chem. 1997. PMID: 9195917 Free article.

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