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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M; CVD50 consortium; Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sacerdote C, Salomaa V, Sánchez MJ, Sattar N, Sharp SJ, Sims R, Slimani N, Smith JA, Thompson DJ, Trompet S, Tumino R, van der A DL, van der Schouw YT, Virtamo J, Walker M, Walt… See abstract for full author list ➔ Scott RA, et al. Among authors: eeles ra. Sci Transl Med. 2016 Jun 1;8(341):341ra76. doi: 10.1126/scitranslmed.aad3744. Sci Transl Med. 2016. PMID: 27252175 Free PMC article.
Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer.
Kote-Jarai Z, Easton D, Edwards SM, Jefferies S, Durocher F, Jackson RA, Singh R, Ardern-Jones A, Murkin A, Dearnaley DP, Shearer R, Kirby R, Houlston R, Eeles R; CRC/BPG UK Familial Prostate Cancer Study Collaborators. Kote-Jarai Z, et al. Among authors: eeles r. Pharmacogenetics. 2001 Jun;11(4):325-30. doi: 10.1097/00008571-200106000-00007. Pharmacogenetics. 2001. PMID: 11434510
Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.
Kote-Jarai Z, Durocher F, Edwards SM, Hamoudi R, Jackson RA, Ardern-Jones A, Murkin A, Dearnaley DP, Kirby R, Houlston R, Easton DF, Eeles R; CRC/BPG UK Familial Prostrate Cancer Collaborators. Kote-Jarai Z, et al. Among authors: eeles r. Prostate Cancer Prostatic Dis. 2002;5(3):189-92. doi: 10.1038/sj.pcan.4500569. Prostate Cancer Prostatic Dis. 2002. PMID: 12496980
Association between hormonal genetic polymorphisms and early-onset prostate cancer.
Forrest MS, Edwards SM, Houlston R, Kote-Jarai Z, Key T, Allen N, Knowles MA, Turner F, Ardern-Jones A, Murkin A, Williams S, Oram R, Bishop DT, Eeles RA; CR-UK/BPG UK prostate cancer study collaborators. Forrest MS, et al. Among authors: eeles ra. Prostate Cancer Prostatic Dis. 2005;8(1):95-102. doi: 10.1038/sj.pcan.4500785. Prostate Cancer Prostatic Dis. 2005. PMID: 15711606
Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer.
Hope Q, Bullock S, Evans C, Meitz J, Hamel N, Edwards SM, Severi G, Dearnaley D, Jhavar S, Southgate C, Falconer A, Dowe A, Muir K, Houlston RS, Engert JC, Roquis D, Sinnett D, Simard J, Heimdal K, Møller P, Maehle L, Badzioch M, Eeles RA, Easton DF, English DR, Southey MC, Hopper JL, Foulkes WD, Giles GG; Cancer Research UK/British Association of Urological Surgeons' Section of Oncology Collaborators. Hope Q, et al. Among authors: eeles ra. Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):397-402. doi: 10.1158/1055-9965.EPI-04-0202. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15734964 Free article.
550 results