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The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models.
Fridkis-Hareli M, Storek M, Or E, Altman R, Katti S, Sun F, Peng T, Hunter J, Johnson K, Wang Y, Lundberg AS, Mehta G, Banda NK, Michael Holers V. Fridkis-Hareli M, et al. Among authors: wang y. Mol Immunol. 2019 Jan;105:150-164. doi: 10.1016/j.molimm.2018.09.013. Epub 2018 Dec 1. Mol Immunol. 2019. PMID: 30513451 Free PMC article.
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