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Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.
Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, Komurov K, Weirauch MT, Cancelas JA, Maciejewski JP, Starczynowski DT. Fang J, et al. Among authors: komurov k. Cell Rep. 2014 Sep 11;8(5):1328-38. doi: 10.1016/j.celrep.2014.07.062. Epub 2014 Sep 4. Cell Rep. 2014. PMID: 25199827 Free PMC article.
Enhanced MAPK signaling is essential for CSF3R-induced leukemia.
Rohrabaugh S, Kesarwani M, Kincaid Z, Huber E, Leddonne J, Siddiqui Z, Khalifa Y, Komurov K, Grimes HL, Azam M. Rohrabaugh S, et al. Among authors: komurov k. Leukemia. 2017 Aug;31(8):1770-1778. doi: 10.1038/leu.2016.376. Epub 2016 Dec 27. Leukemia. 2017. PMID: 28031554 Free PMC article.
KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.
Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA. Zhang C, et al. Among authors: komurov k. Oncotarget. 2018 Jul 3;9(51):29665-29679. doi: 10.18632/oncotarget.25667. eCollection 2018 Jul 3. Oncotarget. 2018. PMID: 30038712 Free PMC article.
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.
Smith MA, Choudhary GS, Pellagatti A, Choi K, Bolanos LC, Bhagat TD, Gordon-Mitchell S, Von Ahrens D, Pradhan K, Steeples V, Kim S, Steidl U, Walter M, Fraser IDC, Kulkarni A, Salomonis N, Komurov K, Boultwood J, Verma A, Starczynowski DT. Smith MA, et al. Among authors: komurov k. Nat Cell Biol. 2019 May;21(5):640-650. doi: 10.1038/s41556-019-0314-5. Epub 2019 Apr 22. Nat Cell Biol. 2019. PMID: 31011167 Free PMC article.
AMP kinase promotes glioblastoma bioenergetics and tumour growth.
Chhipa RR, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, Chen X, Waclaw R, Chow LM, Khuchua Z, Kofron M, Weirauch MT, Kendler A, McPherson C, Ratner N, Nakano I, Dasgupta N, Komurov K, Dasgupta B. Chhipa RR, et al. Among authors: komurov k. Nat Cell Biol. 2018 Jul;20(7):823-835. doi: 10.1038/s41556-018-0126-z. Epub 2018 Jun 18. Nat Cell Biol. 2018. PMID: 29915361 Free PMC article.
Defective transcription elongation in a subset of cancers confers immunotherapy resistance.
Modur V, Singh N, Mohanty V, Chung E, Muhammad B, Choi K, Chen X, Chetal K, Ratner N, Salomonis N, Weirauch MT, Waltz S, Huang G, Privette-Vinnedge L, Park JS, Janssen EM, Komurov K. Modur V, et al. Among authors: komurov k. Nat Commun. 2018 Oct 23;9(1):4410. doi: 10.1038/s41467-018-06810-0. Nat Commun. 2018. PMID: 30353012 Free PMC article.
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