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Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.
Steringer JP, Bleicken S, Andreas H, Zacherl S, Laussmann M, Temmerman K, Contreras FX, Bharat TA, Lechner J, Müller HM, Briggs JA, García-Sáez AJ, Nickel W. Steringer JP, et al. Among authors: muller hm. J Biol Chem. 2012 Aug 10;287(33):27659-69. doi: 10.1074/jbc.M112.381939. Epub 2012 Jun 23. J Biol Chem. 2012. PMID: 22730382 Free PMC article.
Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.
Müller HM, Steringer JP, Wegehingel S, Bleicken S, Münster M, Dimou E, Unger S, Weidmann G, Andreas H, García-Sáez AJ, Wild K, Sinning I, Nickel W. Müller HM, et al. J Biol Chem. 2015 Apr 3;290(14):8925-37. doi: 10.1074/jbc.M114.622456. Epub 2015 Feb 18. J Biol Chem. 2015. PMID: 25694424 Free PMC article.
258 results