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HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies.
Fouda GG, Yates NL, Pollara J, Shen X, Overman GR, Mahlokozera T, Wilks AB, Kang HH, Salazar-Gonzalez JF, Salazar MG, Kalilani L, Meshnick SR, Hahn BH, Shaw GM, Lovingood RV, Denny TN, Haynes B, Letvin NL, Ferrari G, Montefiori DC, Tomaras GD, Permar SR; Center for HIV/AIDS Vaccine Immunology. Fouda GG, et al. J Virol. 2011 Sep;85(18):9555-67. doi: 10.1128/JVI.05174-11. Epub 2011 Jul 6. J Virol. 2011. PMID: 21734046 Free PMC article.
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.
Friedman J, Alam SM, Shen X, Xia SM, Stewart S, Anasti K, Pollara J, Fouda GG, Yang G, Kelsoe G, Ferrari G, Tomaras GD, Haynes BF, Liao HX, Moody MA, Permar SR. Friedman J, et al. Among authors: permar sr. PLoS One. 2012;7(5):e37648. doi: 10.1371/journal.pone.0037648. Epub 2012 May 18. PLoS One. 2012. PMID: 22624058 Free PMC article.
Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants.
Fouda GG, Mahlokozera T, Salazar-Gonzalez JF, Salazar MG, Learn G, Kumar SB, Dennison SM, Russell E, Rizzolo K, Jaeger F, Cai F, Vandergrift NA, Gao F, Hahn B, Shaw GM, Ochsenbauer C, Swanstrom R, Meshnick S, Mwapasa V, Kalilani L, Fiscus S, Montefiori D, Haynes B, Kwiek J, Alam SM, Permar SR. Fouda GG, et al. Among authors: permar sr. Retrovirology. 2013 Jan 10;10:3. doi: 10.1186/1742-4690-10-3. Retrovirology. 2013. PMID: 23305422 Free PMC article.
Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk.
Fouda GG, Amos JD, Wilks AB, Pollara J, Ray CA, Chand A, Kunz EL, Liebl BE, Whitaker K, Carville A, Smith S, Colvin L, Pickup DJ, Staats HF, Overman G, Eutsey-Lloyd K, Parks R, Chen H, Labranche C, Barnett S, Tomaras GD, Ferrari G, Montefiori DC, Liao HX, Letvin NL, Haynes BF, Permar SR. Fouda GG, et al. Among authors: permar sr. J Virol. 2013 Jun;87(12):6986-99. doi: 10.1128/JVI.00528-13. Epub 2013 Apr 17. J Virol. 2013. PMID: 23596289 Free PMC article.
Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.
Amos JD, Wilks AB, Fouda GG, Smith SD, Colvin L, Mahlokozera T, Ho C, Beck K, Overman RG, DeMarco CT, Hodge TL, LaBranche CC, Montefiori DC, Denny TN, Liao HX, Tomaras GD, Moody MA, Permar SR. Amos JD, et al. J Virol. 2013 Oct;87(20):11121-34. doi: 10.1128/JVI.01887-13. Epub 2013 Aug 7. J Virol. 2013. PMID: 23926338 Free PMC article.
Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.
Fouda GG, Jaeger FH, Amos JD, Ho C, Kunz EL, Anasti K, Stamper LW, Liebl BE, Barbas KH, Ohashi T, Moseley MA, Liao HX, Erickson HP, Alam SM, Permar SR. Fouda GG, et al. Among authors: permar sr. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18220-5. doi: 10.1073/pnas.1307336110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145401 Free PMC article.
Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide.
Dennison SM, Anasti KM, Jaeger FH, Stewart SM, Pollara J, Liu P, Kunz EL, Zhang R, Vandergrift N, Permar S, Ferrari G, Tomaras GD, Bonsignori M, Michael NL, Kim JH, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Liao HX, Haynes BF, Alam SM. Dennison SM, et al. Among authors: permar s. J Virol. 2014 Aug;88(16):9406-17. doi: 10.1128/JVI.01031-14. Epub 2014 Jun 11. J Virol. 2014. PMID: 24920809 Free PMC article.
Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.
Sacha CR, Vandergrift N, Jeffries TL Jr, McGuire E, Fouda GG, Liebl B, Marshall DJ, Gurley TC, Stiegel L, Whitesides JF, Friedman J, Badiabo A, Foulger A, Yates NL, Tomaras GD, Kepler TB, Liao HX, Haynes BF, Moody MA, Permar SR. Sacha CR, et al. Among authors: permar sr. Mucosal Immunol. 2015 Mar;8(2):316-26. doi: 10.1038/mi.2014.69. Epub 2014 Aug 6. Mucosal Immunol. 2015. PMID: 25100291 Free PMC article.
278 results