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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.
Lynch JJ 3rd, Rossignol E, Moehrle JJ, Van Vleet TR, Marsh KC, Parman T, Mirsalis J, Ottinger SE, Segreti JA, Rao M, Mittelstadt SW. Lynch JJ 3rd, et al. Among authors: ottinger se. J Pharmacol Toxicol Methods. 2019 Sep-Oct;99:106580. doi: 10.1016/j.vascn.2019.106580. Epub 2019 May 11. J Pharmacol Toxicol Methods. 2019. PMID: 31085318 Free PMC article.