Hu H - Search Results

1

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM. Juvekar A, et al. Among authors: hu h. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4338-47. doi: 10.1073/pnas.1522223113. Epub 2016 Jul 8. Proc Natl Acad Sci U S A. 2016. PMID: 27402769 Free PMC article.

2

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.

Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM. Juvekar A, et al. Among authors: hu h. Cancer Discov. 2012 Nov;2(11):1048-63. doi: 10.1158/2159-8290.CD-11-0336. Epub 2012 Aug 22. Cancer Discov. 2012. PMID: 22915751 Free PMC article.

3

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, Asara JM, Cantley LC, Wulf GM. Hu H, et al. Cell. 2016 Jan 28;164(3):433-46. doi: 10.1016/j.cell.2015.12.042. Cell. 2016. PMID: 26824656 Free PMC article.

4

Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice.

Burga LN, Hu H, Juvekar A, Tung NM, Troyan SL, Hofstatter EW, Wulf GM. Burga LN, et al. Among authors: hu h. Breast Cancer Res. 2011 Mar 11;13(2):R30. doi: 10.1186/bcr2850. Breast Cancer Res. 2011. PMID: 21396117 Free PMC article.

5

The amplifier effect: how Pin1 empowers mutant p53.

Hu H, Wulf GM. Hu H, et al. Breast Cancer Res. 2011 Oct 13;13(5):315. doi: 10.1186/bcr2941. Breast Cancer Res. 2011. PMID: 22017796 Free PMC article.

6

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Lien EC, et al. Among authors: hu h. Nat Cell Biol. 2016 May;18(5):572-8. doi: 10.1038/ncb3341. Epub 2016 Apr 18. Nat Cell Biol. 2016. PMID: 27088857 Free PMC article.

7

Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation.

Hu H, Luo ML, Desmedt C, Nabavi S, Yadegarynia S, Hong A, Konstantinopoulos PA, Gabrielson E, Hines-Boykin R, Pihan G, Yuan X, Sotiriou C, Dittmer DP, Fingeroth JD, Wulf GM. Hu H, et al. EBioMedicine. 2016 Jul;9:148-160. doi: 10.1016/j.ebiom.2016.05.025. Epub 2016 May 21. EBioMedicine. 2016. PMID: 27333046 Free PMC article.

8

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. Wei S, et al. Among authors: hu h. Nat Med. 2015 May;21(5):457-66. doi: 10.1038/nm.3839. Epub 2015 Apr 13. Nat Med. 2015. PMID: 25849135 Free PMC article.

9

Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer.

Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Luo ML, et al. Among authors: hu h. Cancer Res. 2014 Jul 1;74(13):3603-16. doi: 10.1158/0008-5472.CAN-13-2785. Epub 2014 May 1. Cancer Res. 2014. PMID: 24786790 Free PMC article.

10

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.

Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Luo ML, et al. Among authors: hu h. Cell Rep. 2015 Apr 7;11(1):111-24. doi: 10.1016/j.celrep.2015.03.002. Epub 2015 Mar 26. Cell Rep. 2015. PMID: 25818297 Free PMC article.

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