Spengler RM - Search Results

1

Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.

Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL. Spengler RM, et al. Nucleic Acids Res. 2016 Sep 6;44(15):7120-31. doi: 10.1093/nar/gkw640. Epub 2016 Jul 14. Nucleic Acids Res. 2016. PMID: 27418678 Free PMC article.

2

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.

Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL. Boudreau RL, et al. Among authors: spengler rm. Nucleic Acids Res. 2013 Jan 7;41(1):e9. doi: 10.1093/nar/gks797. Epub 2012 Aug 31. Nucleic Acids Res. 2013. PMID: 22941647 Free PMC article.

3

Transcriptome-wide discovery of microRNA binding sites in human brain.

Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL. Boudreau RL, et al. Among authors: spengler rm. Neuron. 2014 Jan 22;81(2):294-305. doi: 10.1016/j.neuron.2013.10.062. Epub 2014 Jan 2. Neuron. 2014. PMID: 24389009 Free PMC article.

4

Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease.

Boudreau RL, Spengler RM, Davidson BL. Boudreau RL, et al. Among authors: spengler rm. Mol Ther. 2011 Dec;19(12):2169-77. doi: 10.1038/mt.2011.185. Epub 2011 Sep 27. Mol Ther. 2011. PMID: 21952166 Free PMC article.

5

Functional microRNAs and target sites are created by lineage-specific transposition.

Spengler RM, Oakley CK, Davidson BL. Spengler RM, et al. Hum Mol Genet. 2014 Apr 1;23(7):1783-93. doi: 10.1093/hmg/ddt569. Epub 2013 Nov 13. Hum Mol Genet. 2014. PMID: 24234653 Free PMC article.

6

Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain.

Monteys AM, Spengler RM, Dufour BD, Wilson MS, Oakley CK, Sowada MJ, McBride JL, Davidson BL. Monteys AM, et al. Among authors: spengler rm. Nucleic Acids Res. 2014 Dec 1;42(21):13315-27. doi: 10.1093/nar/gku979. Epub 2014 Oct 20. Nucleic Acids Res. 2014. PMID: 25332397 Free PMC article.

7

Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo.

Monteys AM, Wilson MJ, Boudreau RL, Spengler RM, Davidson BL. Monteys AM, et al. Among authors: spengler rm. Mol Ther Nucleic Acids. 2015 Apr 7;4:e234. doi: 10.1038/mtna.2015.7. Mol Ther Nucleic Acids. 2015. PMID: 25849618 Free article.

8

Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts.

Ramachandran S, Coffin SL, Tang TY, Jobaliya CD, Spengler RM, Davidson BL. Ramachandran S, et al. Among authors: spengler rm. Hum Mol Genet. 2016 Nov 15;25(22):4939-4950. doi: 10.1093/hmg/ddw317. Hum Mol Genet. 2016. PMID: 28171541 Free PMC article.

9

Adenosine deamination in human transcripts generates novel microRNA binding sites.

Borchert GM, Gilmore BL, Spengler RM, Xing Y, Lanier W, Bhattacharya D, Davidson BL. Borchert GM, et al. Among authors: spengler rm. Hum Mol Genet. 2009 Dec 15;18(24):4801-7. doi: 10.1093/hmg/ddp443. Epub 2009 Sep 23. Hum Mol Genet. 2009. PMID: 19776031 Free PMC article.

10

Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution.

McLoughlin HS, Wan J, Spengler RM, Xing Y, Davidson BL. McLoughlin HS, et al. Among authors: spengler rm. Hum Mol Genet. 2014 May 15;23(10):2593-603. doi: 10.1093/hmg/ddt655. Epub 2013 Dec 23. Hum Mol Genet. 2014. PMID: 24368418

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