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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. Dannappel M, et al. Among authors: pasparakis m. Nature. 2014 Sep 4;513(7516):90-4. doi: 10.1038/nature13608. Epub 2014 Aug 17. Nature. 2014. PMID: 25132550 Free PMC article.
Necroptosis and its role in inflammation.
Pasparakis M, Vandenabeele P. Pasparakis M, et al. Nature. 2015 Jan 15;517(7534):311-20. doi: 10.1038/nature14191. Nature. 2015. PMID: 25592536 Review.
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M. Lin J, et al. Among authors: pasparakis m. Nature. 2016 Dec 1;540(7631):124-128. doi: 10.1038/nature20558. Epub 2016 Nov 7. Nature. 2016. PMID: 27819681 Free PMC article.
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition.
Gräb J, Suárez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch C, Pasparakis M, Kashkar H, Rybniker J. Gräb J, et al. Among authors: pasparakis m. Nat Commun. 2019 Feb 8;10(1):688. doi: 10.1038/s41467-019-08405-9. Nat Commun. 2019. PMID: 30737374 Free PMC article.
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H. Fritsch M, et al. Among authors: pasparakis m. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20. Nature. 2019. PMID: 31748744
201 results