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The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.
Dudek M, Yang N, Ruckshanthi JP, Williams J, Borysiewicz E, Wang P, Adamson A, Li J, Bateman JF, White MR, Boot-Handford RP, Hoyland JA, Meng QJ. Dudek M, et al. Among authors: li j. Ann Rheum Dis. 2017 Mar;76(3):576-584. doi: 10.1136/annrheumdis-2016-209428. Epub 2016 Aug 3. Ann Rheum Dis. 2017. PMID: 27489225 Free PMC article.
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS. Meng QJ, et al. Among authors: li j. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5. doi: 10.1073/pnas.1005101107. Epub 2010 Aug 9. Proc Natl Acad Sci U S A. 2010. PMID: 20696890 Free PMC article.
COPD lung studies of Nrf2 expression and the effects of Nrf2 activators.
Li J, Baker J, Higham A, Shah R, Montero-Fernandez A, Murray C, Cooper N, Lucas C, Fox C, Singh D, Lea S. Li J, et al. Inflammopharmacology. 2022 Aug;30(4):1431-1443. doi: 10.1007/s10787-022-00967-3. Epub 2022 Apr 20. Inflammopharmacology. 2022. PMID: 35441963 Free PMC article.
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