Mangold JB - Search Results

1

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.

Flarakos J, Du Y, Gu H, Wang L, Einolf HJ, Chun DY, Zhu B, Alexander N, Natrillo A, Hanna I, Ting L, Zhou W, Dole K, Sun H, Kovacs SJ, Stein DS, Tanaka SK, Villano S, Mangold JB. Flarakos J, et al. Among authors: mangold jb. Xenobiotica. 2017 Aug;47(8):682-696. doi: 10.1080/00498254.2016.1213465. Epub 2016 Aug 8. Xenobiotica. 2017. PMID: 27499331

2

Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats.

Lin W, Flarakos J, Du Y, Hu W, He H, Mangold J, Tanaka SK, Villano S. Lin W, et al. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01784-16. doi: 10.1128/AAC.01784-16. Print 2017 Jan. Antimicrob Agents Chemother. 2016. PMID: 27821446 Free PMC article.

3

Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.

Flarakos J, Du Y, Bedman T, Al-Share Q, Jordaan P, Chandra P, Albrecht D, Wang L, Gu H, Einolf HJ, Huskey SE, Mangold JB. Flarakos J, et al. Among authors: mangold jb. Xenobiotica. 2016 Nov;46(11):986-1000. doi: 10.3109/00498254.2015.1014944. Epub 2016 Mar 2. Xenobiotica. 2016. PMID: 26931777

4

Disposition and metabolism of [¹⁴C]PTZ601 in healthy volunteers.

Flarakos J, Ting LS, Du Y, Stein DS, Reynolds CV, Patel M, Roy S, Mangold JB. Flarakos J, et al. Among authors: mangold jb. Xenobiotica. 2013 Mar;43(3):283-92. doi: 10.3109/00498254.2012.715696. Epub 2012 Aug 29. Xenobiotica. 2013. PMID: 22931187 Clinical Trial.

5

Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects.

Dhuria S, Einolf H, Mangold J, Sen S, Gu H, Wang L, Cameron S. Dhuria S, et al. J Clin Pharmacol. 2013 Jun;53(6):642-53. doi: 10.1002/jcph.79. Epub 2013 Apr 15. J Clin Pharmacol. 2013. PMID: 23585187

6

Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.

He H, Tran P, Yin H, Smith H, Batard Y, Wang L, Einolf H, Gu H, Mangold JB, Fischer V, Howard D. He H, et al. Among authors: mangold jb. Drug Metab Dispos. 2009 Mar;37(3):536-44. doi: 10.1124/dmd.108.023010. Epub 2008 Dec 15. Drug Metab Dispos. 2009. PMID: 19074975

7

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G. Xia B, et al. Among authors: mangold jb. Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4. Eur J Pharm Sci. 2014. PMID: 25008118

8

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB. Huskey SE, et al. Among authors: mangold jb. Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26. Drug Metab Dispos. 2016. PMID: 26921386

9

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.

Einolf HJ, Lin W, Won CS, Wang L, Gu H, Chun DY, He H, Mangold JB. Einolf HJ, et al. Among authors: mangold jb. Drug Metab Dispos. 2017 Dec;45(12):1304-1316. doi: 10.1124/dmd.117.076851. Epub 2017 Sep 14. Drug Metab Dispos. 2017. PMID: 28912253

10

Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.

Mangold JB, Gu H, Rodriguez LC, Bonner J, Dickson J, Rordorf C. Mangold JB, et al. Drug Metab Dispos. 2004 May;32(5):566-71. doi: 10.1124/dmd.32.5.566. Drug Metab Dispos. 2004. PMID: 15100180

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