Fishwick CW - Search Results

1

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Brem J, et al. Among authors: fishwick cw. Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406. Nat Commun. 2016. PMID: 27499424 Free PMC article.

2

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: fishwick cw. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.

3

Structure guided development of potent reversibly binding penicillin binding protein inhibitors.

Woon EC, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CW, Gobec S, Charlier P, Luxen A, Schofield CJ. Woon EC, et al. Among authors: fishwick cw. ACS Med Chem Lett. 2011 Jan 11;2(3):219-23. doi: 10.1021/ml100260x. eCollection 2011 Mar 10. ACS Med Chem Lett. 2011. PMID: 24900305 Free PMC article.

4

Applications of structure-based design to antibacterial drug discovery.

Cain R, Narramore S, McPhillie M, Simmons K, Fishwick CW. Cain R, et al. Among authors: fishwick cw. Bioorg Chem. 2014 Aug;55:69-76. doi: 10.1016/j.bioorg.2014.05.008. Epub 2014 Jun 2. Bioorg Chem. 2014. PMID: 24962384 Review.

5

Computational methods to identify new antibacterial targets.

McPhillie MJ, Cain RM, Narramore S, Fishwick CW, Simmons KJ. McPhillie MJ, et al. Among authors: fishwick cw. Chem Biol Drug Des. 2015 Jan;85(1):22-9. doi: 10.1111/cbdd.12385. Chem Biol Drug Des. 2015. PMID: 24974974

6

Cyclic Boronates Inhibit All Classes of β-Lactamases.

Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J. Cahill ST, et al. Among authors: fishwick cw. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02260-16. doi: 10.1128/AAC.02260-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28115348 Free PMC article.

7

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment.

Dilly SJ, Clark AJ, Marsh A, Mitchell DA, Cain R, Fishwick CWG, Taylor PC. Dilly SJ, et al. Cancer Lett. 2017 May 1;393:16-21. doi: 10.1016/j.canlet.2017.01.042. Epub 2017 Feb 8. Cancer Lett. 2017. PMID: 28188816 Free article.

8

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Calvopiña K, et al. Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21. Mol Microbiol. 2017. PMID: 28876489 Free article.

9

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.

Batson S, de Chiara C, Majce V, Lloyd AJ, Gobec S, Rea D, Fülöp V, Thoroughgood CW, Simmons KJ, Dowson CG, Fishwick CWG, de Carvalho LPS, Roper DI. Batson S, et al. Among authors: fishwick cwg. Nat Commun. 2017 Dec 5;8(1):1939. doi: 10.1038/s41467-017-02118-7. Nat Commun. 2017. PMID: 29208891 Free PMC article.

10

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG. Cain R, et al. J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10. J Med Chem. 2018. PMID: 29271657 Free article.

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