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Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Cooper IR, McCarroll AJ, McGarry D, Kirkham J, Pichowicz M, Walker R, Warrilow C, Salisbury AM, Savage VJ, Moyo E, Forward H, Cheung J, Metzger R, Gault Z, Nelson G, Hughes D, Cao S, Maclean J, Charrier C, Craighead M, Best S, Stokes NR, Ratcliffe AJ. Cooper IR, et al. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4179-83. doi: 10.1016/j.bmcl.2016.07.061. Epub 2016 Jul 28. Bioorg Med Chem Lett. 2016. PMID: 27499455 Free article.
Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.
Charrier C, Salisbury AM, Savage VJ, Duffy T, Moyo E, Chaffer-Malam N, Ooi N, Newman R, Cheung J, Metzger R, McGarry D, Pichowicz M, Sigerson R, Cooper IR, Nelson G, Butler HS, Craighead M, Ratcliffe AJ, Best SA, Stokes NR. Charrier C, et al. Among authors: cooper ir. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02100-16. doi: 10.1128/AAC.02100-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223393 Free PMC article.
Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.
McGarry DH, Cooper IR, Walker R, Warrilow CE, Pichowicz M, Ratcliffe AJ, Salisbury AM, Savage VJ, Moyo E, Maclean J, Smith A, Charrier C, Stokes NR, Lindsay DM, Kerr WJ. McGarry DH, et al. Among authors: cooper ir. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2998-3003. doi: 10.1016/j.bmcl.2018.05.049. Epub 2018 May 26. Bioorg Med Chem Lett. 2018. PMID: 30122228 Free article.
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Lyons A, Kirkham J, Blades K, Orr D, Dauncey E, Smith O, Dick E, Walker R, Matthews T, Bunt A, Finlayson J, Morrison I, Savage VJ, Moyo E, Butler HS, Newman R, Ooi N, Smith A, Charrier C, Ratcliffe AJ, Stokes NR, Best S, Salisbury AM, Craighead M, Cooper IR. Lyons A, et al. Among authors: cooper ir. Bioorg Med Chem Lett. 2022 Jun 1;65:128648. doi: 10.1016/j.bmcl.2022.128648. Epub 2022 Feb 26. Bioorg Med Chem Lett. 2022. PMID: 35231579
Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
Henderson SR, Stevenson CEM, Malone B, Zholnerovych Y, Mitchenall LA, Pichowicz M, McGarry DH, Cooper IR, Charrier C, Salisbury AM, Lawson DM, Maxwell A. Henderson SR, et al. Among authors: cooper ir. J Antimicrob Chemother. 2020 Oct 1;75(10):2835-2842. doi: 10.1093/jac/dkaa286. J Antimicrob Chemother. 2020. PMID: 32728686 Free PMC article.
47 results