Ratcliffe PJ - Search Results

1

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.

Platt JL, Salama R, Smythies J, Choudhry H, Davies JO, Hughes JR, Ratcliffe PJ, Mole DR. Platt JL, et al. Among authors: ratcliffe pj. EMBO Rep. 2016 Oct;17(10):1410-1421. doi: 10.15252/embr.201642198. Epub 2016 Aug 8. EMBO Rep. 2016. PMID: 27506891 Free PMC article.

2

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Cockman ME, et al. Among authors: ratcliffe pj. J Biol Chem. 2000 Aug 18;275(33):25733-41. doi: 10.1074/jbc.M002740200. J Biol Chem. 2000. PMID: 10823831 Free article.

3

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Jaakkola P, et al. Among authors: ratcliffe pj. Science. 2001 Apr 20;292(5516):468-72. doi: 10.1126/science.1059796. Epub 2001 Apr 5. Science. 2001. PMID: 11292861

4

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER. Clifford SC, et al. Among authors: ratcliffe pj. Hum Mol Genet. 2001 May 1;10(10):1029-38. doi: 10.1093/hmg/10.10.1029. Hum Mol Genet. 2001. PMID: 11331613

5

Activation of the HIF pathway in cancer.

Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Among authors: ratcliffe pj. Curr Opin Genet Dev. 2001 Jun;11(3):293-9. doi: 10.1016/s0959-437x(00)00193-3. Curr Opin Genet Dev. 2001. PMID: 11377966 Review.

6

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.

Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Masson N, et al. Among authors: ratcliffe pj. EMBO J. 2001 Sep 17;20(18):5197-206. doi: 10.1093/emboj/20.18.5197. EMBO J. 2001. PMID: 11566883 Free PMC article.

7

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: ratcliffe pj. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.

8

The HIF pathway: implications for patterns of gene expression in cancer.

Wykoff CC, Pugh CW, Harris AL, Maxwell PH, Ratcliffe PJ. Wykoff CC, et al. Among authors: ratcliffe pj. Novartis Found Symp. 2001;240:212-25; discussion 225-31. doi: 10.1002/0470868716.ch15. Novartis Found Symp. 2001. PMID: 11727931 Review.

9

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ. Mole DR, et al. Among authors: ratcliffe pj. IUBMB Life. 2001 Jul;52(1-2):43-7. doi: 10.1080/15216540252774757. IUBMB Life. 2001. PMID: 11795592 Free article. Review.

10

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.

Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Mole DR, et al. Among authors: ratcliffe pj. Adv Enzyme Regul. 2002;42:333-47. doi: 10.1016/s0065-2571(01)00037-1. Adv Enzyme Regul. 2002. PMID: 12123724 No abstract available.

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