Mole DJ - Search Results

1

ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy.

Nixon M, Mackenzie SD, Taylor AI, Homer NZ, Livingstone DE, Mouras R, Morgan RA, Mole DJ, Stimson RH, Reynolds RM, Elfick AP, Andrew R, Walker BR. Nixon M, et al. Among authors: mole dj. Sci Transl Med. 2016 Aug 17;8(352):352ra109. doi: 10.1126/scitranslmed.aaf9074. Sci Transl Med. 2016. PMID: 27535620

2

Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.

Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP. Wilson K, et al. Among authors: mole dj. Protein Expr Purif. 2014 Mar;95(100):96-103. doi: 10.1016/j.pep.2013.11.015. Epub 2013 Dec 4. Protein Expr Purif. 2014. PMID: 24316190 Free PMC article.

3

A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.

Wilson K, Mole DJ, Homer NZ, Iredale JP, Auer M, Webster SP. Wilson K, et al. Among authors: mole dj. J Biomol Screen. 2015 Feb;20(2):292-8. doi: 10.1177/1087057114554171. Epub 2014 Oct 8. J Biomol Screen. 2015. PMID: 25296660

4

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP. Mole DJ, et al. Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11. Nat Med. 2016. PMID: 26752518 Free PMC article.

5

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.

Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L, Hayes AJ, Tsoumanis A, Lyster D, Parks RW, Garden OJ, Iredale JP, Uings IJ, Liddle J, Wright WL, Dukes G, Webster SP, Mole DJ. Skouras C, et al. Among authors: mole dj. Sci Rep. 2016 Sep 27;6:33951. doi: 10.1038/srep33951. Sci Rep. 2016. PMID: 27669975 Free PMC article.

6

Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct.

Stimson RH, Anderson AJ, Ramage LE, Macfarlane DP, de Beaux AC, Mole DJ, Andrew R, Walker BR. Stimson RH, et al. Among authors: mole dj. Diabetes Obes Metab. 2017 Jun;19(6):883-891. doi: 10.1111/dom.12899. Epub 2017 Mar 28. Diabetes Obes Metab. 2017. PMID: 28177189 Free PMC article. Clinical Trial.

7

Detecting drug-target binding in cells using fluorescence-activated cell sorting coupled with mass spectrometry analysis.

Wilson K, Webster SP, Iredale JP, Zheng X, Homer NZ, Pham NT, Auer M, Mole DJ. Wilson K, et al. Among authors: mole dj. Methods Appl Fluoresc. 2017 Dec 15;6(1):015002. doi: 10.1088/2050-6120/aa8c60. Methods Appl Fluoresc. 2017. PMID: 28901950 Free article.

8

Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants.

Jackson-Jones LH, Smith P, Portman JR, Magalhaes MS, Mylonas KJ, Vermeren MM, Nixon M, Henderson BEP, Dobie R, Vermeren S, Denby L, Henderson NC, Mole DJ, Bénézech C. Jackson-Jones LH, et al. Among authors: mole dj. Immunity. 2020 Apr 14;52(4):700-715.e6. doi: 10.1016/j.immuni.2020.03.011. Immunity. 2020. PMID: 32294409 Free PMC article.

9

Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis.

Lemos H, Mohamed E, Ou R, McCardle C, Zheng X, McGuire K, Homer NZM, Mole DJ, Huang L, Mellor AL. Lemos H, et al. Among authors: mole dj. Front Immunol. 2020 Jun 17;11:1256. doi: 10.3389/fimmu.2020.01256. eCollection 2020. Front Immunol. 2020. PMID: 32625215 Free PMC article.

10

Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice.

Puigoriol-Illamola D, Companys-Alemany J, McGuire K, Homer NZM, Leiva R, Vázquez S, Mole DJ, Griñán-Ferré C, Pallàs M. Puigoriol-Illamola D, et al. Among authors: mole dj. Pharmaceuticals (Basel). 2021 Oct 13;14(10):1040. doi: 10.3390/ph14101040. Pharmaceuticals (Basel). 2021. PMID: 34681264 Free PMC article.

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