Wan H - Search Results

1

Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Zhu Y, Li L, Zhang G, Wan H, Yang C, Diao X, Chen X, Zhang L, Zhong D. Zhu Y, et al. Among authors: wan h. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:117-127. doi: 10.1016/j.jchromb.2016.08.009. Epub 2016 Aug 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27541626 Clinical Trial.

2

Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers.

Lu B, Cao H, Cao J, Huang S, Hu Q, Liu D, Shen R, Shen X, Tao W, Wan H, Wang D, Yan Y, Yang L, Zhang J, Zhang L, Zhang L, Zhang M. Lu B, et al. Among authors: wan h. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-823. doi: 10.1016/j.bmcl.2015.12.086. Epub 2015 Dec 24. Bioorg Med Chem Lett. 2016. PMID: 26739779

3

WITHDRAWN: Discovery of SHR1977: A highly potent and selective ROMK inhibitor.

Li X, Zhang Y, Chen Y, He W, Wan H, Zhang L, Hu Q, Feng J, Yuan J, Dong Q, Cao G, Zhang L, He F, Bai C, Tao W. Li X, et al. Among authors: wan h. Bioorg Med Chem Lett. 2016 Jun 27:S0960-894X(16)30683-7. doi: 10.1016/j.bmcl.2016.06.072. Online ahead of print. Bioorg Med Chem Lett. 2016. PMID: 27377326

4

Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer.

Li X, Yang C, Wan H, Zhang G, Feng J, Zhang L, Chen X, Zhong D, Lou L, Tao W, Zhang L. Li X, et al. Among authors: wan h. Eur J Pharm Sci. 2017 Dec 15;110:51-61. doi: 10.1016/j.ejps.2017.01.021. Epub 2017 Jan 21. Eur J Pharm Sci. 2017. PMID: 28115222

5

Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.

Lu B, Huang S, Cao J, Hu Q, Shen R, Wan H, Wang D, Yuan J, Zhang L, Zhang J, Zhang M, Tao W, Zhang L. Lu B, et al. Among authors: wan h. Bioorg Med Chem. 2018 Feb 1;26(3):581-589. doi: 10.1016/j.bmc.2017.12.019. Epub 2017 Dec 20. Bioorg Med Chem. 2018. PMID: 29317148

6

Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma.

Lu B, Shen X, Zhang L, Liu D, Zhang C, Cao J, Shen R, Zhang J, Wang D, Wan H, Xu Z, Ho MH, Zhang M, Zhang L, He F, Tao W. Lu B, et al. Among authors: wan h. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. doi: 10.1021/acsmedchemlett.7b00437. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456795 Free PMC article.

7

Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy.

Hu Q, Ye X, Qu X, Cui D, Zhang L, Xu Z, Wan H, Zhang L, Tao W. Hu Q, et al. Among authors: wan h. Sci Rep. 2018 May 16;8(1):7675. doi: 10.1038/s41598-018-25987-4. Sci Rep. 2018. PMID: 29769573 Free PMC article.

8

Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.

Tu W, Yang F, Xu G, Chi J, Liu Z, Peng W, Hu B, Zhang L, Wan H, Yu N, Jin F, Hu Q, Zhang L, He F, Tao W. Tu W, et al. Among authors: wan h. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953. doi: 10.1021/acsmedchemlett.9b00114. eCollection 2019 Jun 13. ACS Med Chem Lett. 2019. PMID: 31223453 Free PMC article.

9

Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration.

Li X, Zhang Z, Chen Y, Wan H, Sun J, Wang B, Feng B, Hu B, Shi X, Feng J, Zhang L, He F, Bai C, Zhang L, Tao W. Li X, et al. Among authors: wan h. ACS Med Chem Lett. 2019 May 29;10(6):996-1001. doi: 10.1021/acsmedchemlett.9b00186. eCollection 2019 Jun 13. ACS Med Chem Lett. 2019. PMID: 31223461 Free PMC article.

10

Discovery of SHR9352: A Highly Potent G Protein-Biased μ-Opioid Receptor Agonist.

Li X, He W, Chen Y, Yang G, Wan H, Zhang L, Hu Q, Feng J, Zhang Z, He F, Bai C, Zhang L, You L, Tao W. Li X, et al. Among authors: wan h. ACS Omega. 2017 Dec 28;2(12):9261-9267. doi: 10.1021/acsomega.7b01452. eCollection 2017 Dec 31. ACS Omega. 2017. PMID: 31457439 Free PMC article.

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