Parrott N - Search Results

1

Effect of Food and Esomeprazole on the Pharmacokinetics of Alectinib, a Highly Selective ALK Inhibitor, in Healthy Subjects.

Morcos PN, Guerini E, Parrott N, Dall G, Blotner S, Bogman K, Sturm C, Balas B, Martin-Facklam M, Phipps A. Morcos PN, et al. Among authors: parrott n. Clin Pharmacol Drug Dev. 2017 Jul;6(4):388-397. doi: 10.1002/cpdd.296. Epub 2016 Sep 28. Clin Pharmacol Drug Dev. 2017. PMID: 27545320 Clinical Trial.

2

Physiologically based pharmacokinetic modelling to predict single- and multiple-dose human pharmacokinetics of bitopertin.

Parrott N, Hainzl D, Alberati D, Hofmann C, Robson R, Boutouyrie B, Martin-Facklam M. Parrott N, et al. Clin Pharmacokinet. 2013 Aug;52(8):673-83. doi: 10.1007/s40262-013-0061-x. Clin Pharmacokinet. 2013. PMID: 23591780 Clinical Trial.

3

Physiologically based absorption modelling to predict the impact of drug properties on pharmacokinetics of bitopertin.

Parrott N, Hainzl D, Scheubel E, Krimmer S, Boetsch C, Guerini E, Martin-Facklam M. Parrott N, et al. AAPS J. 2014 Sep;16(5):1077-84. doi: 10.1208/s12248-014-9639-y. Epub 2014 Jun 27. AAPS J. 2014. PMID: 24970349 Free PMC article.

4

Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.

Boetsch C, Parrott N, Fowler S, Poirier A, Hainzl D, Banken L, Martin-Facklam M, Hofmann C. Boetsch C, et al. Among authors: parrott n. Clin Pharmacokinet. 2016 Feb;55(2):237-47. doi: 10.1007/s40262-015-0312-0. Clin Pharmacokinet. 2016. PMID: 26341813 Clinical Trial.

5

Combining 'Bottom-Up' and 'Top-Down' Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example.

Feng S, Shi J, Parrott N, Hu P, Weber C, Martin-Facklam M, Saito T, Peck R. Feng S, et al. Among authors: parrott n. Clin Pharmacokinet. 2016 Jul;55(7):823-832. doi: 10.1007/s40262-015-0356-1. Clin Pharmacokinet. 2016. PMID: 26715215 Free PMC article.

6

Physiologically Based Absorption Modeling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Alectinib.

Parrott NJ, Yu LJ, Takano R, Nakamura M, Morcos PN. Parrott NJ, et al. AAPS J. 2016 Nov;18(6):1464-1474. doi: 10.1208/s12248-016-9957-3. Epub 2016 Jul 22. AAPS J. 2016. PMID: 27450228 Clinical Trial.

7

Effect of the Wetting Agent Sodium Lauryl Sulfate on the Pharmacokinetics of Alectinib: Results From a Bioequivalence Study in Healthy Subjects.

Morcos PN, Parrott N, Banken L, Timpe C, Lindenberg M, Guerini E, Dall G, Bogman K, Sturm C, Zeaiter A, Martin-Facklam M, Phipps A. Morcos PN, et al. Among authors: parrott n. Clin Pharmacol Drug Dev. 2017 May;6(3):266-279. doi: 10.1002/cpdd.299. Epub 2016 Oct 3. Clin Pharmacol Drug Dev. 2017. PMID: 27545871 Clinical Trial.

8

Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.

Fowler S, Guerini E, Qiu N, Cleary Y, Parrott N, Greig G, Mallalieu NL. Fowler S, et al. Among authors: parrott n. J Pharmacol Exp Ther. 2017 Jan;360(1):164-173. doi: 10.1124/jpet.116.237214. Epub 2016 Nov 7. J Pharmacol Exp Ther. 2017. PMID: 27821711 Clinical Trial.

9

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.

Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L. Fowler S, et al. Among authors: parrott n. Curr Pharmacol Rep. 2017;3(1):36-49. doi: 10.1007/s40495-017-0082-5. Epub 2017 Feb 1. Curr Pharmacol Rep. 2017. PMID: 28261547 Free PMC article. Review.

10

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.

Cleary Y, Gertz M, Morcos PN, Yu L, Youdim K, Phipps A, Fowler S, Parrott N. Cleary Y, et al. Among authors: parrott n. Clin Pharmacol Ther. 2018 Sep;104(3):505-514. doi: 10.1002/cpt.956. Epub 2017 Dec 27. Clin Pharmacol Ther. 2018. PMID: 29226313

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