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An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis.
Paller AS, Renert-Yuval Y, Suprun M, Esaki H, Oliva M, Huynh TN, Ungar B, Kunjravia N, Friedland R, Peng X, Zheng X, Estrada YD, Krueger JG, Choate KA, Suárez-Fariñas M, Guttman-Yassky E. Paller AS, et al. Among authors: huynh tn. J Allergy Clin Immunol. 2017 Jan;139(1):152-165. doi: 10.1016/j.jaci.2016.07.019. Epub 2016 Aug 20. J Allergy Clin Immunol. 2017. PMID: 27554821 Free PMC article.
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin.
Esaki H, Brunner PM, Renert-Yuval Y, Czarnowicki T, Huynh T, Tran G, Lyon S, Rodriguez G, Immaneni S, Johnson DB, Bauer B, Fuentes-Duculan J, Zheng X, Peng X, Estrada YD, Xu H, de Guzman Strong C, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E. Esaki H, et al. J Allergy Clin Immunol. 2016 Dec;138(6):1639-1651. doi: 10.1016/j.jaci.2016.07.013. Epub 2016 Sep 23. J Allergy Clin Immunol. 2016. PMID: 27671162
Alterations in B-cell subsets in pediatric patients with early atopic dermatitis.
Czarnowicki T, Esaki H, Gonzalez J, Renert-Yuval Y, Brunner P, Oliva M, Estrada Y, Xu H, Zheng X, Talasila S, Haugh I, Huynh T, Lyon S, Tran G, Sampson H, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E, Paller AS. Czarnowicki T, et al. J Allergy Clin Immunol. 2017 Jul;140(1):134-144.e9. doi: 10.1016/j.jaci.2016.09.060. Epub 2016 Dec 10. J Allergy Clin Immunol. 2017. PMID: 27965110
Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations.
Brunner PM, Israel A, Zhang N, Leonard A, Wen HC, Huynh T, Tran G, Lyon S, Rodriguez G, Immaneni S, Wagner A, Zheng X, Estrada YD, Xu H, Krueger JG, Paller AS, Guttman-Yassky E. Brunner PM, et al. J Allergy Clin Immunol. 2018 Jun;141(6):2094-2106. doi: 10.1016/j.jaci.2018.02.040. Epub 2018 May 3. J Allergy Clin Immunol. 2018. PMID: 29731129
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Malik K, He H, Huynh TN, Tran G, Mueller K, Doytcheva K, Renert-Yuval Y, Czarnowicki T, Magidi S, Chou M, Estrada YD, Wen HC, Peng X, Xu H, Zheng X, Krueger JG, Paller AS, Guttman-Yassky E. Malik K, et al. Among authors: huynh tn. J Allergy Clin Immunol. 2019 Feb;143(2):604-618. doi: 10.1016/j.jaci.2018.03.021. Epub 2018 May 24. J Allergy Clin Immunol. 2019. PMID: 29803800 Free PMC article.
159 results