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Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.
Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palacín M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Bach D, et al. Among authors: zorzano a. Diabetes. 2005 Sep;54(9):2685-93. doi: 10.2337/diabetes.54.9.2685. Diabetes. 2005. PMID: 16123358
Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients.
Hernández-Alvarez MI, Chiellini C, Manco M, Naon D, Liesa M, Palacín M, Mingrone G, Zorzano A. Hernández-Alvarez MI, et al. Among authors: zorzano a. Diabetologia. 2009 Aug;52(8):1618-27. doi: 10.1007/s00125-009-1403-y. Epub 2009 Jun 6. Diabetologia. 2009. PMID: 19504086 Free article.
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.
Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ. Hernández-Alvarez MI, et al. Among authors: zorzano a. Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23. Diabetes Care. 2010. PMID: 20032281 Free PMC article. Clinical Trial.
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A. Sebastián D, et al. Among authors: zorzano a. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5523-8. doi: 10.1073/pnas.1108220109. Epub 2012 Mar 16. Proc Natl Acad Sci U S A. 2012. PMID: 22427360 Free PMC article.
Mfn2 modulates the UPR and mitochondrial function via repression of PERK.
Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, Díaz-Ramos A, Hernández-Alvarez MI, Sebastián D, Mauvezin C, Palacín M, Zorzano A. Muñoz JP, et al. Among authors: zorzano a. EMBO J. 2013 Aug 28;32(17):2348-61. doi: 10.1038/emboj.2013.168. Epub 2013 Aug 6. EMBO J. 2013. PMID: 23921556 Free PMC article.
374 results