Unger GM - Search Results

1

CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors.

Ahmed K, Kren BT, Abedin MJ, Vogel RI, Shaughnessy DP, Nacusi L, Korman VL, Li Y, Dehm SM, Zimmerman CL, Niehans GA, Unger GM, Trembley JH. Ahmed K, et al. Among authors: unger gm. Oncotarget. 2016 Sep 20;7(38):61789-61805. doi: 10.18632/oncotarget.11442. Oncotarget. 2016. PMID: 27557516 Free PMC article.

2

Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.

Trembley JH, Unger GM, Tobolt DK, Korman VL, Wang G, Ahmad KA, Slaton JW, Kren BT, Ahmed K. Trembley JH, et al. Among authors: unger gm. Mol Cell Biochem. 2011 Oct;356(1-2):21-35. doi: 10.1007/s11010-011-0943-x. Epub 2011 Jul 15. Mol Cell Biochem. 2011. PMID: 21761204 Free PMC article.

3

Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.

Trembley JH, Unger GM, Korman VL, Tobolt DK, Kazimierczuk Z, Pinna LA, Kren BT, Ahmed K. Trembley JH, et al. Among authors: unger gm. Cancer Lett. 2012 Feb 1;315(1):48-58. doi: 10.1016/j.canlet.2011.10.007. Epub 2011 Oct 12. Cancer Lett. 2012. PMID: 22050909 Free PMC article.

4

Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma.

Unger GM, Kren BT, Korman VL, Kimbrough TG, Vogel RI, Ondrey FG, Trembley JH, Ahmed K. Unger GM, et al. Mol Cancer Ther. 2014 Aug;13(8):2018-29. doi: 10.1158/1535-7163.MCT-14-0166. Epub 2014 May 27. Mol Cancer Ther. 2014. PMID: 24867250 Free PMC article.

5

Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice.

Trembley JH, Unger GM, Korman VL, Abedin MJ, Nacusi LP, Vogel RI, Slaton JW, Kren BT, Ahmed K. Trembley JH, et al. Among authors: unger gm. PLoS One. 2014 Oct 15;9(10):e109970. doi: 10.1371/journal.pone.0109970. eCollection 2014. PLoS One. 2014. PMID: 25333839 Free PMC article.

6

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.

Kren BT, Unger GM, Abedin MJ, Vogel RI, Henzler CM, Ahmed K, Trembley JH. Kren BT, et al. Among authors: unger gm. Breast Cancer Res. 2015;17:19. doi: 10.1186/s13058-015-0524-0. Epub 2015 Feb 11. Breast Cancer Res. 2015. PMID: 25837326 Free PMC article.

7

Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation.

Trembley JH, Unger GM, Gomez OC, Abedin J, Korman VL, Vogel RI, Niehans G, Kren BT, Ahmed K. Trembley JH, et al. Among authors: unger gm. Mol Cell Pharmacol. 2014;6(2):15-25. Mol Cell Pharmacol. 2014. PMID: 25893034 Free PMC article.

8

CK2 Molecular Targeting-Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer.

Trembley JH, Kren BT, Abedin MJ, Vogel RI, Cannon CM, Unger GM, Ahmed K. Trembley JH, et al. Among authors: unger gm. Pharmaceuticals (Basel). 2017 Feb 21;10(1):25. doi: 10.3390/ph10010025. Pharmaceuticals (Basel). 2017. PMID: 28230733 Free PMC article. Review.

9

Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer.

Cannon CM, Trembley JH, Kren BT, Unger GM, O'Sullivan MG, Cornax I, Modiano JF, Ahmed K. Cannon CM, et al. Among authors: unger gm. Hum Gene Ther Clin Dev. 2017 Jun;28(2):80-86. doi: 10.1089/humc.2017.008. Epub 2017 Mar 23. Hum Gene Ther Clin Dev. 2017. PMID: 28335614 Free PMC article.

10

Protein kinase CK2 in health and disease: CK2: a key player in cancer biology.

Trembley JH, Wang G, Unger G, Slaton J, Ahmed K. Trembley JH, et al. Cell Mol Life Sci. 2009 Jun;66(11-12):1858-67. doi: 10.1007/s00018-009-9154-y. Cell Mol Life Sci. 2009. PMID: 19387548 Free PMC article. Review.

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