Miller MS - Search Results

1

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ.

Miller MS, Mountford SJ, Pinson JA, Zheng Z, Künzli M, Patel V, Hogg SJ, Shortt J, Jennings IG, Thompson PE. Miller MS, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4790-4794. doi: 10.1016/j.bmcl.2016.08.028. Epub 2016 Aug 11. Bioorg Med Chem Lett. 2016. PMID: 27561716

2

Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase.

Miller MS, Pinson JA, Zheng Z, Jennings IG, Thompson PE. Miller MS, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):802-5. doi: 10.1016/j.bmcl.2012.11.076. Epub 2012 Dec 1. Bioorg Med Chem Lett. 2013. PMID: 23265896

3

Mechanisms of PI3Kβ-selective inhibition revealed by reciprocal mutagenesis.

Zheng Z, Miller MS, Jennings IG, Thompson PE. Zheng Z, et al. Among authors: miller ms. ACS Chem Biol. 2013 Apr 19;8(4):679-83. doi: 10.1021/cb300666s. Epub 2013 Feb 6. ACS Chem Biol. 2013. PMID: 23360067

4

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ.

Pinson JA, Zheng Z, Miller MS, Chalmers DK, Jennings IG, Thompson PE. Pinson JA, et al. Among authors: miller ms. ACS Med Chem Lett. 2013 Feb 14;4(2):206-210. doi: 10.1021/ml300336j. ACS Med Chem Lett. 2013. PMID: 23795239 Free PMC article.

5

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Miller MS, et al. Oncotarget. 2014 Jul 30;5(14):5198-208. doi: 10.18632/oncotarget.2263. Oncotarget. 2014. PMID: 25105564 Free PMC article.

6

Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.

Miller MS, Maheshwari S, McRobb FM, Kinzler KW, Amzel LM, Vogelstein B, Gabelli SB. Miller MS, et al. Bioorg Med Chem. 2017 Feb 15;25(4):1481-1486. doi: 10.1016/j.bmc.2017.01.012. Epub 2017 Jan 16. Bioorg Med Chem. 2017. PMID: 28129991 Free PMC article.

7

Structural Determinants of Isoform Selectivity in PI3K Inhibitors.

Miller MS, Thompson PE, Gabelli SB. Miller MS, et al. Biomolecules. 2019 Feb 26;9(3):82. doi: 10.3390/biom9030082. Biomolecules. 2019. PMID: 30813656 Free PMC article. Review.

8

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO. Zhang F, et al. Among authors: miller ms. J Med Chem. 2013 May 23;56(10):3996-4016. doi: 10.1021/jm400227z. Epub 2013 May 1. J Med Chem. 2013. PMID: 23634668 Free PMC article.

9

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation.

Miller MS, Douglass J, Hwang MS, Skora AD, Murphy M, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB. Miller MS, et al. J Biol Chem. 2019 Dec 13;294(50):19322-19334. doi: 10.1074/jbc.RA119.010251. Epub 2019 Nov 5. J Biol Chem. 2019. PMID: 31690625 Free PMC article.

10

Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition.

Maheshwari S, Miller MS, O'Meally R, Cole RN, Amzel LM, Gabelli SB. Maheshwari S, et al. Among authors: miller ms. J Biol Chem. 2017 Aug 18;292(33):13541-13550. doi: 10.1074/jbc.M116.772426. Epub 2017 Jul 4. J Biol Chem. 2017. PMID: 28676499 Free PMC article.

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