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Page 1
Transversions have larger regulatory effects than transitions.
Guo C, McDowell IC, Nodzenski M, Scholtens DM, Allen AS, Lowe WL, Reddy TE. Guo C, et al. Among authors: mcdowell ic. BMC Genomics. 2017 May 19;18(1):394. doi: 10.1186/s12864-017-3785-4. BMC Genomics. 2017. PMID: 28525990 Free PMC article.
A long-range flexible billboard model of gene activation.
Vockley CM, McDowell IC, D'Ippolito AM, Reddy TE. Vockley CM, et al. Among authors: mcdowell ic. Transcription. 2017 Aug 8;8(4):261-267. doi: 10.1080/21541264.2017.1317694. Epub 2017 Jun 9. Transcription. 2017. PMID: 28598247 Free PMC article.
Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids.
D'Ippolito AM, McDowell IC, Barrera A, Hong LK, Leichter SM, Bartelt LC, Vockley CM, Majoros WH, Safi A, Song L, Gersbach CA, Crawford GE, Reddy TE. D'Ippolito AM, et al. Among authors: mcdowell ic. Cell Syst. 2018 Aug 22;7(2):146-160.e7. doi: 10.1016/j.cels.2018.06.007. Epub 2018 Jul 18. Cell Syst. 2018. PMID: 30031775 Free article.
Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding.
McDowell IC, Barrera A, D'Ippolito AM, Vockley CM, Hong LK, Leichter SM, Bartelt LC, Majoros WH, Song L, Safi A, Koçak DD, Gersbach CA, Hartemink AJ, Crawford GE, Engelhardt BE, Reddy TE. McDowell IC, et al. Genome Res. 2018 Sep;28(9):1272-1284. doi: 10.1101/gr.233346.117. Epub 2018 Aug 10. Genome Res. 2018. PMID: 30097539 Free PMC article.
Human genome-wide measurement of drug-responsive regulatory activity.
Johnson GD, Barrera A, McDowell IC, D'Ippolito AM, Majoros WH, Vockley CM, Wang X, Allen AS, Reddy TE. Johnson GD, et al. Among authors: mcdowell ic. Nat Commun. 2018 Dec 21;9(1):5317. doi: 10.1038/s41467-018-07607-x. Nat Commun. 2018. PMID: 30575722 Free PMC article.
Epigenome editing of the CFTR-locus for treatment of cystic fibrosis.
Kabadi AM, Machlin L, Dalal N, Lee RE, McDowell I, Shah NN, Drowley L, Randell SH, Reddy TE. Kabadi AM, et al. J Cyst Fibros. 2022 Jan;21(1):164-171. doi: 10.1016/j.jcf.2021.04.008. Epub 2021 May 25. J Cyst Fibros. 2022. PMID: 34049825 Free PMC article.
Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13.
Ang HX, Sutiman N, Deng XL, Liu A, Cerda-Smith CG, Hutchinson HM, Kim H, Bartelt LC, Chen Q, Barrera A, Lin J, Sheng Z, McDowell IC, Reddy TE, Nicchitta CV, Wood KC. Ang HX, et al. Among authors: mcdowell ic. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2221448120. doi: 10.1073/pnas.2221448120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695916 Free PMC article.
21 results