Leszczynska G - Search Results

1

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization.

Sierant M, Leszczynska G, Sadowska K, Dziergowska A, Rozanski M, Sochacka E, Nawrot B. Sierant M, et al. Among authors: leszczynska g. Nucleic Acids Res. 2016 Dec 15;44(22):10986-10998. doi: 10.1093/nar/gkw727. Epub 2016 Aug 26. Nucleic Acids Res. 2016. PMID: 27566149 Free PMC article.

2

mt-tRNA components: synthesis of (2-thio)uridines modified with blocked glycine/taurine moieties at C-5,1.

Leszczynska G, Leonczak P, Dziergowska A, Malkiewicz A. Leszczynska G, et al. Nucleosides Nucleotides Nucleic Acids. 2013;32(11):599-616. doi: 10.1080/15257770.2013.838261. Nucleosides Nucleotides Nucleic Acids. 2013. PMID: 24138499

3

Site-selected incorporation of 5-carboxymethylaminomethyl(-2-thio)uridine into RNA sequences by phosphoramidite chemistry.

Leszczynska G, Pięta J, Wozniak K, Malkiewicz A. Leszczynska G, et al. Org Biomol Chem. 2014 Feb 21;12(7):1052-6. doi: 10.1039/c3ob42302f. Org Biomol Chem. 2014. PMID: 24407195 Free article.

4

Chemical synthesis of the 5-taurinomethyl(-2-thio)uridine modified anticodon arm of the human mitochondrial tRNA(Leu(UUR)) and tRNA(Lys).

Leszczynska G, Leonczak P, Wozniak K, Malkiewicz A. Leszczynska G, et al. RNA. 2014 Jun;20(6):938-47. doi: 10.1261/rna.044412.114. Epub 2014 Apr 22. RNA. 2014. PMID: 24757169 Free PMC article.

5

An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products.

Chwialkowska A, Wielgus E, Leszczynska G, Sobczak M, Mikolajczyk B, Sochacka E, Nawrot B. Chwialkowska A, et al. Among authors: leszczynska g. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3100-4. doi: 10.1016/j.bmcl.2015.06.019. Epub 2015 Jun 12. Bioorg Med Chem Lett. 2015. PMID: 26112441

6

Nucleoside modifications in the regulation of gene expression: focus on tRNA.

Duechler M, Leszczyńska G, Sochacka E, Nawrot B. Duechler M, et al. Among authors: leszczynska g. Cell Mol Life Sci. 2016 Aug;73(16):3075-95. doi: 10.1007/s00018-016-2217-y. Epub 2016 Apr 19. Cell Mol Life Sci. 2016. PMID: 27094388 Free PMC article. Review.

7

C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3΄-end of the mRNA codons.

Sochacka E, Lodyga-Chruscinska E, Pawlak J, Cypryk M, Bartos P, Ebenryter-Olbinska K, Leszczynska G, Nawrot B. Sochacka E, et al. Among authors: leszczynska g. Nucleic Acids Res. 2017 May 5;45(8):4825-4836. doi: 10.1093/nar/gkw1347. Nucleic Acids Res. 2017. PMID: 28088758 Free PMC article.

8

Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine.

Bartosik K, Sochacka E, Leszczynska G. Bartosik K, et al. Among authors: leszczynska g. Org Biomol Chem. 2017 Mar 1;15(9):2097-2103. doi: 10.1039/c6ob02674e. Org Biomol Chem. 2017. PMID: 28217770

9

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.

Leszczynska G, Sadowska K, Sierant M, Sobczak M, Nawrot B, Sochacka E. Leszczynska G, et al. Org Biomol Chem. 2017 Jun 27;15(25):5332-5336. doi: 10.1039/c7ob01012e. Org Biomol Chem. 2017. PMID: 28617513

10

Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate.

Sierant M, Leszczynska G, Sadowska K, Komar P, Radzikowska-Cieciura E, Sochacka E, Nawrot B. Sierant M, et al. Among authors: leszczynska g. FEBS Lett. 2018 Jul;592(13):2248-2258. doi: 10.1002/1873-3468.13124. Epub 2018 Jun 19. FEBS Lett. 2018. PMID: 29862510 Free article.

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