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Page 1
Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.
Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S. Schuette V, et al. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601670 Free PMC article.
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).
Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J. Vaeth M, et al. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2480-5. doi: 10.1073/pnas.1009463108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262800 Free PMC article.
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, Jonuleit H, Waisman A, Müller MR, Serfling E, Sawitzki BS, Berberich-Siebelt F. Vaeth M, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16258-63. doi: 10.1073/pnas.1203870109. Epub 2012 Sep 18. Proc Natl Acad Sci U S A. 2012. PMID: 22991461 Free PMC article.
NFATc1 controls the cytotoxicity of CD8+ T cells.
Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E. Klein-Hessling S, et al. Nat Commun. 2017 Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6. Nat Commun. 2017. PMID: 28894104 Free PMC article.
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
Xiao Y, Qureischi M, Dietz L, Vaeth M, Vallabhapurapu SD, Klein-Hessling S, Klein M, Liang C, König A, Serfling E, Mottok A, Bopp T, Rosenwald A, Buttmann M, Berberich I, Beilhack A, Berberich-Siebelt F. Xiao Y, et al. J Exp Med. 2021 Jan 4;218(1):e20181853. doi: 10.1084/jem.20181853. J Exp Med. 2021. PMID: 32986812 Free PMC article.
61 results