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Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.
Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T. Tanaka S, et al. Among authors: sakane s. Hepatology. 2016 Dec;64(6):1994-2014. doi: 10.1002/hep.28820. Epub 2016 Oct 21. Hepatology. 2016. PMID: 27637015
Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.
Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T. Myojin Y, et al. Among authors: sakane s. Gastroenterology. 2021 Apr;160(5):1741-1754.e16. doi: 10.1053/j.gastro.2020.12.015. Epub 2020 Dec 17. Gastroenterology. 2021. PMID: 33346004 Free article.
Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration.
Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. Nozaki Y, et al. Among authors: sakane s. Sci Rep. 2021 Feb 9;11(1):3363. doi: 10.1038/s41598-021-83082-7. Sci Rep. 2021. PMID: 33564095 Free PMC article.
Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis.
Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T. Mizutani N, et al. Among authors: sakane s. Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1;320(6):G958-G968. doi: 10.1152/ajpgi.00370.2020. Epub 2021 Mar 31. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 33787344 Free article.
Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis.
Kozumi K, Kodama T, Murai H, Sakane S, Govaere O, Cockell S, Motooka D, Kakita N, Yamada Y, Kondo Y, Tahata Y, Yamada R, Hikita H, Sakamori R, Kamada Y, Daly AK, Anstee QM, Tatsumi T, Morii E, Takehara T. Kozumi K, et al. Among authors: sakane s. Hepatology. 2021 Nov;74(5):2452-2466. doi: 10.1002/hep.31995. Epub 2021 Aug 21. Hepatology. 2021. PMID: 34105780 Free PMC article.
White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice.
Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. Sakane S, et al. Cell Mol Gastroenterol Hepatol. 2021;12(5):1683-1699. doi: 10.1016/j.jcmgh.2021.07.008. Epub 2021 Jul 22. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34303881 Free PMC article.
Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver.
Urabe M, Hikita H, Saito Y, Kudo S, Fukumoto K, Mizutani N, Myojin Y, Doi A, Sato K, Sakane S, Makino Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. Urabe M, et al. Among authors: sakane s. Hepatol Commun. 2022 Feb;6(2):411-422. doi: 10.1002/hep4.1815. Epub 2021 Sep 28. Hepatol Commun. 2022. PMID: 34585534 Free PMC article.
89 results