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Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor.
Kaye J, Piryatinsky V, Birnberg T, Hingaly T, Raymond E, Kashi R, Amit-Romach E, Caballero IS, Towfic F, Ator MA, Rubinstein E, Laifenfeld D, Orbach A, Shinar D, Marantz Y, Grossman I, Knappertz V, Hayden MR, Laufer R. Kaye J, et al. Among authors: piryatinsky v. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6145-E6152. doi: 10.1073/pnas.1607843113. Epub 2016 Sep 26. Proc Natl Acad Sci U S A. 2016. PMID: 27671624 Free PMC article.
Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination.
Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, Wegner C. Brück W, et al. Among authors: piryatinsky v. Acta Neuropathol. 2012 Sep;124(3):411-24. doi: 10.1007/s00401-012-1009-1. Epub 2012 Jul 6. Acta Neuropathol. 2012. PMID: 22766690 Free PMC article.