Clark AC - Search Results

1

Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection.

Maciag JJ, Mackenzie SH, Tucker MB, Schipper JL, Swartz P, Clark AC. Maciag JJ, et al. Among authors: clark ac. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6080-E6088. doi: 10.1073/pnas.1603549113. Epub 2016 Sep 28. Proc Natl Acad Sci U S A. 2016. PMID: 27681633 Free PMC article.

2

An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.

Bose K, Pop C, Feeney B, Clark AC. Bose K, et al. Among authors: clark ac. Biochemistry. 2003 Oct 28;42(42):12298-310. doi: 10.1021/bi034998x. Biochemistry. 2003. PMID: 14567691 Free PMC article.

3

Mutations in the procaspase-3 dimer interface affect the activity of the zymogen.

Pop C, Feeney B, Tripathy A, Clark AC. Pop C, et al. Among authors: clark ac. Biochemistry. 2003 Oct 28;42(42):12311-20. doi: 10.1021/bi034999p. Biochemistry. 2003. PMID: 14567692 Free PMC article.

4

Reassembly of active caspase-3 is facilitated by the propeptide.

Feeney B, Clark AC. Feeney B, et al. Among authors: clark ac. J Biol Chem. 2005 Dec 2;280(48):39772-85. doi: 10.1074/jbc.M505834200. Epub 2005 Oct 3. J Biol Chem. 2005. PMID: 16203739 Free PMC article.

5

Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3.

Feeney B, Pop C, Swartz P, Mattos C, Clark AC. Feeney B, et al. Among authors: clark ac. Biochemistry. 2006 Nov 7;45(44):13249-63. doi: 10.1021/bi0611964. Biochemistry. 2006. PMID: 17073446 Free PMC article.

6

Minimizing frustration by folding in an aqueous environment.

Mattos C, Clark AC. Mattos C, et al. Among authors: clark ac. Arch Biochem Biophys. 2008 Jan 1;469(1):118-31. doi: 10.1016/j.abb.2007.07.007. Epub 2007 Jul 14. Arch Biochem Biophys. 2008. PMID: 17719000 Free PMC article.

7

Targeting cell death in tumors by activating caspases.

MacKenzie SH, Clark AC. MacKenzie SH, et al. Among authors: clark ac. Curr Cancer Drug Targets. 2008 Mar;8(2):98-109. doi: 10.2174/156800908783769391. Curr Cancer Drug Targets. 2008. PMID: 18336192 Free PMC article. Review.

8

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.

Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC. Walters J, et al. Among authors: clark ac. Biochem J. 2009 Dec 10;424(3):335-45. doi: 10.1042/BJ20090825. Biochem J. 2009. PMID: 19788411 Free PMC article.

9

Folding and assembly kinetics of procaspase-3.

Milam SL, Clark AC. Milam SL, et al. Among authors: clark ac. Protein Sci. 2009 Dec;18(12):2500-17. doi: 10.1002/pro.259. Protein Sci. 2009. PMID: 19798740 Free PMC article.

10

The potential for caspases in drug discovery.

MacKenzie SH, Schipper JL, Clark AC. MacKenzie SH, et al. Among authors: clark ac. Curr Opin Drug Discov Devel. 2010 Sep;13(5):568-76. Curr Opin Drug Discov Devel. 2010. PMID: 20812148 Free PMC article. Review.

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