Han WT - Search Results

1

A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase.

Balasubramanian N, Brown PJ, Catt JD, Han WT, Parker RA, Sit SY, Wright JJ. Balasubramanian N, et al. Among authors: han wt. J Med Chem. 1989 Sep;32(9):2038-41. doi: 10.1021/jm00129a004. J Med Chem. 1989. PMID: 2769677 No abstract available.

2

Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

Sit SY, Parker RA, Motoc I, Han W, Balasubramanian N, Catt JD, Brown PJ, Harte WE, Thompson MD, Wright JJ. Sit SY, et al. J Med Chem. 1990 Nov;33(11):2982-99. doi: 10.1021/jm00173a013. J Med Chem. 1990. PMID: 2231596

3

Azetidin-2-one derivatives as inhibitors of thrombin.

Han WT, Trehan AK, Wright JJ, Federici ME, Seiler SM, Meanwell NA. Han WT, et al. Bioorg Med Chem. 1995 Aug;3(8):1123-43. doi: 10.1016/0968-0896(95)00101-l. Bioorg Med Chem. 1995. PMID: 7582985

4

Active site-directed thrombin inhibitors--II. Studies related to arginine/guanidine bioisosteres.

St Laurent DR, Balasubramanian N, Han WT, Trehan A, Federici ME, Meanwell NA, Wright JJ, Seiler SM. St Laurent DR, et al. Among authors: han wt. Bioorg Med Chem. 1995 Aug;3(8):1145-56. doi: 10.1016/0968-0896(95)00103-n. Bioorg Med Chem. 1995. PMID: 7582986

5

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.

Hu Z, Wang C, Han W, Rossi KA, Bozarth JM, Wu Y, Sheriff S, Myers JE Jr, Luettgen JM, Seiffert DA, Wexler RR, Quan ML. Hu Z, et al. Bioorg Med Chem Lett. 2018 Apr 1;28(6):987-992. doi: 10.1016/j.bmcl.2018.02.049. Epub 2018 Feb 27. Bioorg Med Chem Lett. 2018. PMID: 29501396

6

Glycine alpha-ketoamides as HCV NS3 protease inhibitors.

Han W, Hu Z, Jiang X, Wasserman ZR, Decicco CP. Han W, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1111-4. doi: 10.1016/s0960-894x(03)00031-3. Bioorg Med Chem Lett. 2003. PMID: 12643923

7

Benzodiazepines as potent and selective bradykinin B1 antagonists.

Wood MR, Kim JJ, Han W, Dorsey BD, Homnick CF, DiPardo RM, Kuduk SD, MacNeil T, Murphy KL, Lis EV, Ransom RW, Stump GL, Lynch JJ, O'Malley SS, Miller PJ, Chen TB, Harrell CM, Chang RS, Sandhu P, Ellis JD, Bondiskey PJ, Pettibone DJ, Freidinger RM, Bock MG. Wood MR, et al. J Med Chem. 2003 May 8;46(10):1803-6. doi: 10.1021/jm034020y. J Med Chem. 2003. PMID: 12723943

8

Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres.

Han W, Jiang X, Hu Z, Wasserman ZR, Decicco CP. Han W, et al. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3487-90. doi: 10.1016/j.bmcl.2005.06.003. Bioorg Med Chem Lett. 2005. PMID: 15982872

9

A potent and orally active HIV-1 integrase inhibitor.

Egbertson MS, Moritz HM, Melamed JY, Han W, Perlow DS, Kuo MS, Embrey M, Vacca JP, Zrada MM, Cortes AR, Wallace A, Leonard Y, Hazuda DJ, Miller MD, Felock PJ, Stillmock KA, Witmer MV, Schleif W, Gabryelski LJ, Moyer G, Ellis JD, Jin L, Xu W, Braun MP, Kassahun K, Tsou NN, Young SD. Egbertson MS, et al. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1392-8. doi: 10.1016/j.bmcl.2006.11.080. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17194584

10

Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.

Shi Y, Sitkoff D, Zhang J, Han W, Hu Z, Stein PD, Wang Y, Kennedy LJ, O'Connor SP, Ahmad S, Liu EC, Seiler SM, Lam PY, Robl JA, Macor JE, Atwal KS, Zahler R. Shi Y, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5952-8. doi: 10.1016/j.bmcl.2007.07.063. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17855089

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