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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors.
Zuhl AM, Nolan CE, Brodney MA, Niessen S, Atchison K, Houle C, Karanian DA, Ambroise C, Brulet JW, Beck EM, Doran SD, O'Neill BT, Am Ende CW, Chang C, Geoghegan KF, West GM, Judkins JC, Hou X, Riddell DR, Johnson DS. Zuhl AM, et al. Among authors: ambroise c. Nat Commun. 2016 Oct 11;7:13042. doi: 10.1038/ncomms13042. Nat Commun. 2016. PMID: 27727204 Free PMC article.
Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
Brodney MA, Barreiro G, Ogilvie K, Hajos-Korcsok E, Murray J, Vajdos F, Ambroise C, Christoffersen C, Fisher K, Lanyon L, Liu J, Nolan CE, Withka JM, Borzilleri KA, Efremov I, Oborski CE, Varghese A, O'Neill BT. Brodney MA, et al. Among authors: ambroise c. J Med Chem. 2012 Nov 8;55(21):9224-39. doi: 10.1021/jm3009426. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22984865
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
O'Neill BT, Beck EM, Butler CR, Nolan CE, Gonzales C, Zhang L, Doran SD, Lapham K, Buzon LM, Dutra JK, Barreiro G, Hou X, Martinez-Alsina LA, Rogers BN, Villalobos A, Murray JC, Ogilvie K, LaChapelle EA, Chang C, Lanyon LF, Steppan CM, Robshaw A, Hales K, Boucher GG, Pandher K, Houle C, Ambroise CW, Karanian D, Riddell D, Bales KR, Brodney MA. O'Neill BT, et al. Among authors: ambroise cw. J Med Chem. 2018 May 24;61(10):4476-4504. doi: 10.1021/acs.jmedchem.8b00246. Epub 2018 Apr 17. J Med Chem. 2018. PMID: 29613789
Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators.
Chappie TA, Abdelmessih M, Ambroise CW, Boehm M, Cai M, Green M, Guilmette E, Steppan CM, Stevens LM, Wei L, Xi S, Hasson SA. Chappie TA, et al. Among authors: ambroise cw. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62. doi: 10.1021/acsmedchemlett.1c00396. eCollection 2022 Jan 13. ACS Med Chem Lett. 2022. PMID: 35059124 Free PMC article.
A strategy for studying epigenetic diversity in natural populations: proof of concept in poplar and oak.
Lesur I, Rogier O, Sow MD, Boury C, Duplan A, Garnier A, Senhaji-Rachik A, Civan P, Daron J, Delaunay A, Duvaux L, Benoit V, Guichoux E, Le Provost G, Sanou E, Ambroise C, Plomion C, Salse J, Segura V, Tost J, Maury S. Lesur I, et al. Among authors: ambroise c. J Exp Bot. 2024 Sep 27;75(18):5568-5584. doi: 10.1093/jxb/erae266. J Exp Bot. 2024. PMID: 38889253
31 results