Soutar MP - Search Results

1

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.

Manzoni C, Mamais A, Roosen DA, Dihanich S, Soutar MP, Plun-Favreau H, Bandopadhyay R, Hardy J, Tooze SA, Cookson MR, Lewis PA. Manzoni C, et al. Among authors: soutar mp. Sci Rep. 2016 Oct 12;6:35106. doi: 10.1038/srep35106. Sci Rep. 2016. PMID: 27731364 Free PMC article.

2

Inhibition of LRRK2 kinase activity stimulates macroautophagy.

Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA. Manzoni C, et al. Biochim Biophys Acta. 2013 Dec;1833(12):2900-2910. doi: 10.1016/j.bbamcr.2013.07.020. Epub 2013 Aug 1. Biochim Biophys Acta. 2013. PMID: 23916833 Free PMC article.

3

Intracellular pH Modulates Autophagy and Mitophagy.

Berezhnov AV, Soutar MP, Fedotova EI, Frolova MS, Plun-Favreau H, Zinchenko VP, Abramov AY. Berezhnov AV, et al. Among authors: soutar mp. J Biol Chem. 2016 Apr 15;291(16):8701-8. doi: 10.1074/jbc.M115.691774. Epub 2016 Feb 18. J Biol Chem. 2016. PMID: 26893374 Free PMC article.

4

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.

Delgado-Camprubi M, Esteras N, Soutar MP, Plun-Favreau H, Abramov AY. Delgado-Camprubi M, et al. Among authors: soutar mp. Cell Death Differ. 2017 Jan;24(1):120-131. doi: 10.1038/cdd.2016.104. Epub 2016 Sep 30. Cell Death Differ. 2017. PMID: 27689878 Free PMC article.

5

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.

Manzoni C, Mamais A, Dihanich S, Soutar MPM, Plun-Favreau H, Bandopadhyay R, Abeti R, Giunti P, Hardy J, R Cookson M, Tooze SA, Lewis PA. Manzoni C, et al. Among authors: soutar mpm. Biosci Rep. 2018 Apr 20;38(2):BSR20171669. doi: 10.1042/BSR20171669. Print 2018 Apr 26. Biosci Rep. 2018. PMID: 29563162 Free PMC article.

6

AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.

Soutar MPM, Kempthorne L, Miyakawa S, Annuario E, Melandri D, Harley J, O'Sullivan GA, Wray S, Hancock DC, Cookson MR, Downward J, Carlton M, Plun-Favreau H. Soutar MPM, et al. Sci Rep. 2018 Jun 11;8(1):8855. doi: 10.1038/s41598-018-26949-6. Sci Rep. 2018. PMID: 29891871 Free PMC article.

7

FBS/BSA media concentration determines CCCP's ability to depolarize mitochondria and activate PINK1-PRKN mitophagy.

Soutar MPM, Kempthorne L, Annuario E, Luft C, Wray S, Ketteler R, Ludtmann MHR, Plun-Favreau H. Soutar MPM, et al. Autophagy. 2019 Nov;15(11):2002-2011. doi: 10.1080/15548627.2019.1603549. Epub 2019 May 7. Autophagy. 2019. PMID: 31060423 Free PMC article.

8

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Soutar MPM, Melandri D, O'Callaghan B, Annuario E, Monaghan AE, Welsh NJ, D'Sa K, Guelfi S, Zhang D, Pittman A, Trabzuni D, Verboven AHA, Pan KS, Kia DA, Bictash M, Gandhi S, Houlden H, Cookson MR, Kasri NN, Wood NW, Singleton AB, Hardy J, Whiting PJ, Blauwendraat C, Whitworth AJ, Manzoni C, Ryten M, Lewis PA, Plun-Favreau H. Soutar MPM, et al. Brain. 2022 Dec 19;145(12):4349-4367. doi: 10.1093/brain/awac325. Brain. 2022. PMID: 36074904 Free PMC article.

9

KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy.

de Talhouët C, Esteras N, Soutar MPM, O'Callaghan B, Plun-Favreau H. de Talhouët C, et al. Among authors: soutar mpm. Sci Rep. 2024 May 22;14(1):11721. doi: 10.1038/s41598-024-60602-9. Sci Rep. 2024. PMID: 38777823 Free PMC article.

10

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.

Delgado-Camprubi M, Esteras N, Soutar MP, Plun-Favreau H, Abramov AY. Delgado-Camprubi M, et al. Among authors: soutar mp. Cell Death Differ. 2017 Dec;24(12):2210. doi: 10.1038/cdd.2017.175. Epub 2017 Oct 13. Cell Death Differ. 2017. PMID: 29027992 Free PMC article.

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