Melnick AM - Search Results

1

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM. Jiang Y, et al. Among authors: melnick am. Cancer Discov. 2017 Jan;7(1):38-53. doi: 10.1158/2159-8290.CD-16-0975. Epub 2016 Oct 12. Cancer Discov. 2017. PMID: 27733359 Free PMC article.

2

AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein.

Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD. Melnick A, et al. Blood. 2000 Dec 1;96(12):3939-47. Blood. 2000. PMID: 11090081 Free article.

3

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms.

Parekh S, Polo JM, Shaknovich R, Juszczynski P, Lev P, Ranuncolo SM, Yin Y, Klein U, Cattoretti G, Dalla Favera R, Shipp MA, Melnick A. Parekh S, et al. Blood. 2007 Sep 15;110(6):2067-74. doi: 10.1182/blood-2007-01-069575. Epub 2007 Jun 1. Blood. 2007. PMID: 17545502 Free PMC article.

4

Sequential transcription factor targeting for diffuse large B-cell lymphomas.

Cerchietti LC, Polo JM, Da Silva GF, Farinha P, Shaknovich R, Gascoyne RD, Dowdy SF, Melnick A. Cerchietti LC, et al. Cancer Res. 2008 May 1;68(9):3361-9. doi: 10.1158/0008-5472.CAN-07-5817. Cancer Res. 2008. PMID: 18451163 Free PMC article.

5

BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner.

Ranuncolo SM, Wang L, Polo JM, Dell'Oso T, Dierov J, Gaymes TJ, Rassool F, Carroll M, Melnick A. Ranuncolo SM, et al. J Biol Chem. 2008 Aug 15;283(33):22565-72. doi: 10.1074/jbc.M803490200. Epub 2008 Jun 4. J Biol Chem. 2008. PMID: 18524763 Free PMC article.

6

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo.

Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy SF, Melnick A. Cerchietti LC, et al. Blood. 2009 Apr 9;113(15):3397-405. doi: 10.1182/blood-2008-07-168773. Epub 2008 Oct 16. Blood. 2009. PMID: 18927431 Free PMC article.

7

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A. Ci W, et al. Blood. 2009 May 28;113(22):5536-48. doi: 10.1182/blood-2008-12-193037. Epub 2009 Mar 23. Blood. 2009. PMID: 19307668 Free PMC article.

8

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.

Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L, Shaknovich R, Bhalla KN, Chiosis G, Melnick A. Cerchietti LC, et al. Nat Med. 2009 Dec;15(12):1369-76. doi: 10.1038/nm.2059. Epub 2009 Nov 22. Nat Med. 2009. PMID: 19966776 Free PMC article.

9

HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes.

Shaknovich R, Figueroa ME, Melnick A. Shaknovich R, et al. Methods Mol Biol. 2010;632:191-201. doi: 10.1007/978-1-60761-663-4_12. Methods Mol Biol. 2010. PMID: 20217579

10

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A. Cerchietti LC, et al. Cancer Cell. 2010 Apr 13;17(4):400-11. doi: 10.1016/j.ccr.2009.12.050. Cancer Cell. 2010. PMID: 20385364 Free PMC article.

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