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An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.
Baakman AC, Alvarez-Jimenez R, Rissmann R, Klaassen ES, Stevens J, Goulooze SC, den Burger JCG, Swart EL, van Gerven JMA, Groeneveld GJ. Baakman AC, et al. Among authors: stevens j. Br J Clin Pharmacol. 2017 Aug;83(8):1676-1687. doi: 10.1111/bcp.13268. Epub 2017 Apr 8. Br J Clin Pharmacol. 2017. PMID: 28217868 Free PMC article. Clinical Trial.
Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.
Alvarez-Jimenez R, Baakman AC, Stevens J, Goulooze SC, Hart EP, Rissmann R, van Gerven JM, Groeneveld GJ. Alvarez-Jimenez R, et al. Among authors: stevens j. J Psychopharmacol. 2017 Feb;31(2):192-203. doi: 10.1177/0269881116681417. Epub 2016 Dec 9. J Psychopharmacol. 2017. PMID: 27927703
First in human study with a prodrug of galantamine: Improved benefit-risk ratio?
Baakman AC, 't Hart E, Kay DG, Stevens J, Klaassen ES, Maelicke A, Groeneveld GJ. Baakman AC, et al. Among authors: stevens j. Alzheimers Dement (N Y). 2016 Jan 20;2(1):13-22. doi: 10.1016/j.trci.2015.12.003. eCollection 2016 Jan. Alzheimers Dement (N Y). 2016. PMID: 29067291 Free PMC article.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Bakker C, Prins S, Liptrot J, Hart EP, Klaassen ES, Brown GA, Brown A, Congreve M, Weir M, Marshall FH, Stevens J, Cross DM, Tasker T, Nathan PJ, Groeneveld GJ. Bakker C, et al. Among authors: stevens j. Br J Clin Pharmacol. 2021 Nov;87(11):4439-4449. doi: 10.1111/bcp.14872. Epub 2021 May 8. Br J Clin Pharmacol. 2021. PMID: 33891333 Free PMC article. Clinical Trial.
Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects.
Spiegelstein O, Stevens J, Van Gerven J, Nathan PJ, Maynard JP, Mayleben DW, Hellriegel E, Yang R. Spiegelstein O, et al. Among authors: stevens j. J Psychopharmacol. 2016 Oct;30(10):983-93. doi: 10.1177/0269881116645301. Epub 2016 May 24. J Psychopharmacol. 2016. PMID: 27222271 Clinical Trial.
4,504 results