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Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.
De Bellis M, Carbonara R, Roussel J, Farinato A, Massari A, Pierno S, Muraglia M, Corbo F, Franchini C, Carratù MR, De Luca A, Conte Camerino D, Desaphy JF. De Bellis M, et al. Among authors: conte camerino d. Neuropharmacology. 2017 Feb;113(Pt A):206-216. doi: 10.1016/j.neuropharm.2016.10.013. Epub 2016 Oct 13. Neuropharmacology. 2017. PMID: 27743929 Free PMC article.
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.
Talon S, De Luca A, De Bellis M, Desaphy JF, Lentini G, Scilimati A, Corbo F, Franchini C, Tortorella P, Jockusch H, Conte Camerino D. Talon S, et al. Among authors: conte camerino d. Br J Pharmacol. 2001 Dec;134(7):1523-31. doi: 10.1038/sj.bjp.0704366. Br J Pharmacol. 2001. PMID: 11724759 Free PMC article.
Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.
De Luca A, Talon S, De Bellis M, Desaphy JF, Franchini C, Lentini G, Catalano A, Corbo F, Tortorella V, Conte-Camerino D. De Luca A, et al. Among authors: conte camerino d. Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):318-27. doi: 10.1007/s00210-002-0669-0. Epub 2003 Jan 25. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12644906
113 results